Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Hiroki YamaguchiDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0003-2409-7401
Nick A GuagliardoDepartment of Pharmacology (N.A.G., L.A.B., M.D., P.Q.B., E.H.N.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0003-2539-1346
Laura A BellDepartment of Pharmacology (N.A.G., L.A.B., M.D., P.Q.B., E.H.N.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0003-0659-5650
Manako YamaguchiDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0002-2880-9165
Daisuke MatsuokaDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0002-2164-0555
Fang XuDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0009-0009-5330-7392
Jason P SmithDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0002-2688-0988
Mohamed DiagneDepartment of Pharmacology (N.A.G., L.A.B., M.D., P.Q.B., E.H.N.), University of Virginia School of Medicine, Charlottesville.ORCID 0009-0002-5801-9997
Sophie CondronDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0009-0009-3275-1558
Lucas F AlmeidaDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0002-5731-1219
Silvia MedranoDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0002-8516-0788
Paula Q BarrettDepartment of Pharmacology (N.A.G., L.A.B., M.D., P.Q.B., E.H.N.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0003-2052-3899
Edward H NiehDepartment of Pharmacology (N.A.G., L.A.B., M.D., P.Q.B., E.H.N.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0003-2154-6224
R Ariel GomezDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0002-5124-8255
Maria Luisa S Sequeira-LopezDepartment of Pediatrics, Child Health Research Center (H.Y., M.Y., D.M., F.X., J.P.S., S.C., L.F.A., S.M., R.A.G., M.L.S.S.-L.), University of Virginia School of Medicine, Charlottesville.ORCID 0000-0002-4459-7940
Funding
Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
Plasticity of renin cells in the kidney vasculatureR01DK116718 · NIDDK · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2018 to 2022
$2.8M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
Signaling and Function of the Adrenal RosetteR01HL138241 · NHLBI · UNIVERSITY OF VIRGINIA · PI GUAGLIARDO, NICK A · 2018 to 2021
$2.1M
Characterizing the underlying population code to understand the functional organization of the hippocampus and the lateral hypothalamusR00DA053388 · NIDA · UNIVERSITY OF VIRGINIA · PI NIEH, HORNG-AN EDWARD · 2023 to 2025
$747k
Investigating the role of NG2-glia in the development of epilepsyK00NS125773 · NINDS · UNIVERSITY OF VIRGINIA · PI Laura Ann Bell · 2023 to 2026
backgroundJuxtaglomerular cells are sensors that control blood pressure and fluid-electrolyte homeostasis. They are arranged as clusters at the tip of each afferent arteriole. In response to decreased blood pressure or extracellular fluid volume, juxtaglomerular cells secrete renin, initiating an enzymatic cascade that culminates in the production of Ang II (angiotensin II), a potent vasoconstrictor that restores blood pressure and fluid-electrolyte homeostasis. In turn, Ang II exerts negative feedback on renin release commensurate with increased intracellular Ca
methodsWe generated mice expressing the juxtaglomerular cell-specific genetically encoded Ca
resultsEx vivo Ca
conclusionsAng II elicits coordinated intracellular and intercellular Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Calcium Oscillations Within Juxtaglomerular Cell Clusters Control Renin Release. · full record | Socratic