ArticleJournal of burn care & research : official publication of the American Burn Association2026
Early Dysregulation of Angiopoietin-1 and -2 as a Predictor of Mortality in Critically Ill Burn Patients.
Article in Journal of burn care & research : official publication of the American Burn Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Role of Angiopoietin-2 in Post-Burn Pneumonia.European burn journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Shock-induced endothelial dysfunction plays a critical role in burn pathophysiology, with endothelial glycocalyx layer degradation promoting systemic inflammation, vascular instability, and multi-organ failure. The angiopoietin-tunica interna endothelial cell kinase (TIE2) axis, particularly the angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) balance, regulates endothelial function; elevated Ang-2 and a high Ang-2/1 ratio are linked to worse outcomes in critical illness. While well-documented in sepsis and trauma, effects of burn-induced angiopoietin dysregulation remain unclear. This study evaluates Ang-1, Ang-2, and the Ang-2/1 ratio as biomarkers of endothelial dysfunction and predictors of 30-day mortality in patients with burn injuries. In this prospective study, 62 adult patients with burn injuries were enrolled (January 2021-November 2024), with serum Ang-1 and Ang-2 measured via enzyme-linked immunosorbent assay on postburn day 1. Of 62 patients, 52 were analyzed; 78.05% of survivors and 90.91% of non-survivors were male. Median age was 45 (survivors) vs 54 years (non-survivors, P = .139). Non-survivors trended toward burns > 20% TBSA (72.73% vs 41.46%, P = .093). Ang-1 was lower in non-survivors (3.96 vs 7.97 ng/mL, P < .001), predicting early mortality (area under the receiver operating characteristic [AUROC]: 0.82) with a cut-off of 4.825 ng/mL and decreased mortality risk (odds ratio [OR]: 0.63, 95% confidence interval [CI]: 0.40-0.87, P = .017). Ang-2 was higher (6.07 vs 1.99 ng/mL, P < .001; AUROC: 0.95), with a cut-off of 3.554 ng/mL. The Ang-2/1 ratio was elevated (1.59 vs 0.23, P < .001; AUROC: 0.93), with a cut-off of 0.504 and increased mortality risk (OR: 2.17, 95% CI: 1.10-5.12, P = .038). Early Ang-1, Ang-2, and Ang-2/1 ratio levels correlate with 30-day mortality and may guide early prognostication.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.