Evidence map›Paper›PMID 40899844›Full record

ArticlemBio2025

Targeting deubiquitinating enzymes and ubiquitin pathway modulators to enhance host defense against bacterial infections.

John Santelices, Alexander Schultz, Alyssa Walker, Nicole Adams, Deyaneira Tirado, Hailey Barker, Aria Eshraghi, Daniel M Czyż, Mariola J Ferraro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The deubiquitinase USP4 stabilizes the SCFNature communications · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

John SantelicesMicrobiology and Cell Science Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA.
Alexander SchultzMicrobiology and Cell Science Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-0183-5056
Alyssa WalkerMicrobiology and Cell Science Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA.
Nicole AdamsDepartment of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0009-0003-2499-7036
Deyaneira TiradoMicrobiology and Cell Science Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA.
Hailey BarkerMicrobiology and Cell Science Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA.
Aria EshraghiDepartment of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-4944-9146
Daniel M CzyżMicrobiology and Cell Science Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-7491-5292
Mariola J FerraroMicrobiology and Cell Science Department, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-0459-7716

Funding

The Function of Host-derived Extracellular Vesicles in Trafficking of Bacterial Antigens to Stimulate the Antibacterial Immune ResponseR01AI158749 · NIAID · UNIVERSITY OF FLORIDA · PI Mariola Jadwiga Ferraro · 2022 to 2026
$2.2M
DOD Peer Reviewed Cancer Research Program W81XWH-20-1-0176National Institute of Allergy and Infectious Diseases AI158749-04NIAID NIH HHS R01 AI158749
6 · The paper itself

Abstract

The rise of antibiotic-resistant bacterial pathogens poses a critical global health challenge, necessitating innovative therapeutic strategies. This study explores host-targeted therapies by focusing on deubiquitinating enzymes (DUBs), key regulators of the ubiquitin-proteasome system (UPS) that mediate host-pathogen interactions. Using

Indexed as

Anti-Bacterial AgentsBacterial InfectionsDeubiquitinating EnzymesHost-Pathogen InteractionsUbiquitinAnimalsHumansKlebsiella pneumoniaeMacrophagesMicePseudomonas aeruginosaAnti-Bacterial AgentsDeubiquitinating EnzymesUbiquitinantimicrobial resistance (AMR)bacterial infectiondeubiquitinating enzymes (DUBs)ESKAPE pathogenshost-targeted therapies (HTTs)immune modulationmacrophage responseSalmonellaubiquitin-proteasome system (UPS)USP25 inhibitor AZ-1

Identifiers

PMID40899844
PMCPMC12506015

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.