ArticleJournal of neurology2025
The impact of autoimmune comorbidities on multiple sclerosis progression: insights from a longitudinal single-center study.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gastrointestinal symptoms and disorders in multiple sclerosis: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- Cladribine use for multiple sclerosis with autoimmune comorbidities: retrospective analysis of the French MS registry, case series, and therapeutic considerations.Therapeutic advances in neurological disorders · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. The presence of other conditions alongside MS imposes a substantial personal and socioeconomic burden. In particular, the impact of comorbid autoimmune diseases (AID) on MS outcomes remains uncertain. In this retrospective longitudinal study, we examined the prevalence of AID in a cohort of patients with different types of MS. For patients with relapsing-remitting MS (RRMS), negative binomial and linear regression models were used to assess adjusted associations between the presence of AID and various other clinical parameters of MS disease. A total of 861 MS patients were included, of whom 148 (17.2%) had one or more comorbid autoimmune diseases (AID). The majority of the patients with MS and AID were women (79.1%). The most prevalent AID was autoimmune thyroiditis (58.1%), followed by psoriasis (16.2%) and type 1 diabetes mellitus (11.5%). Among the 662 RRMS patients, we observed minimal changes in key metrics such as disease-modifying therapies (DMT), relapse rates, steroids dosages, plasma exchanges, or changes in the expanded disability status scale (EDSS) for those with AID. For example, the incident rate of relapses in DMT-naïve patients with AID was nearly identical to that of those without AID (incident rate ratio = 0.92, 95% confidence interval: 0.81 - 1.04). Our findings highlight the notable co-occurrence of AID among patients with MS and suggest that these comorbidities do not affect the progression of RRMS, regardless of DMT use. Reassessing this in large, multicenter, prospective, long-term studies is essential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.