ArticleJournal of nephrology2025
Osteocalcin as a predictor of bone fracture in children with chronic kidney diseases.
Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Circulating Total Osteocalcin Reflects Bone Mineral Physiology Rather than Metabolic Risk in Pediatric Obesity.Nutrients · 2026Article
- Osteocalcin Beyond Bone: Molecular Mechanisms, Endocrine Networks, and Translational Perspectives Across Metabolism, Neurobiology, and Chronic Disease.International journal of molecular sciences · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
backgroundThe associations between biochemical indicators of osteocalcin and bone health are fairly well established in adults through observational studies. In this context, our objective was to assess serum level of uncarboxylated osteocalcin (uOC) and its relation to the incidence of bone fractures other bone health indices in children with CKD.
methodsWe enrolled 102 patients classified into two groups: group A: CKD without KRT; group B: CKD on regular HD. The patients were followed throughout the study period. The study's endpoint was either the occurrence of a bone fracture or the conclusion of the study period. Another 22 healthy individuals were involved as a control group. We measured uOC and various indicators of bone health including bone-specific alkaline phosphatase (BAP) on the same day of the fracture or at the end of the study period.
resultsuOC was found significantly higher in CKD children in comparison to the control group (p <0.001). Moreover, its level was significantly higher in the HD group compared to CKD without KRT group (p = 0.047). In patients with fractures, uOC and BAP were significantly higher compared with patients without fractures (p < 0.001 and 0.019, respectively). By logistic regression analysis, uOC was the only predictor of bone fractures (p = 0.027, OR = 1.011).
conclusionElevated uOC levels were observed in children with CKD who experienced fractures, and these levels showed a correlation with BAP. Furthermore, uOC appears to be a reliable indicator of bone fractures in this population.
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