Evidence map›Paper›PMID 40900413›Full record

ArticleMikrochimica acta2025

An electrochemical immunosensor based on HFABP for the early detection of drug-induced cardiac toxicity from traditional Chinese medicines.

Bolu Sun, Jiali Kang, Zixia Wang, Yuqiong Wu, Haiying He, Xinlan Wang, Xuanxiu Da, Miao Zhou, Ying Lv, Chenyu Qin and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bolu Sun *School of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China. sunbl@lut.edu.cn.
Jiali Kang *School of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China.
Zixia WangDepartment of Pharmacy, Affiliated Hospital of Yangzhou University, Yangzhou, 225012, Jiangsu, China.
Yuqiong WuThe Second People's Hospital of Gansu Province, Lanzhou, Gansu, 730030, China.
Haiying HeSchool of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China.
Xinlan WangSchool of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China.
Xuanxiu DaSchool of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China.
Miao ZhouSchool of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China.
Ying LvSchool of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China.
Chenyu QinSchool of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China.
Xiangdong WangSchool of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China.
Lin YangSchool of Life Science and Engineering, Key Laboratory of Herbal-Tibetan Drug Screening and Deep Processing of Gansu Province, Gansu Industrial Technology Center for Food and Pharmaceutical Resources Development and Biomanufacturing, Lanzhou University of Technology, Lanzhou, Gansu, 730050, China. yanglin-401@163.com.
Huajie LiThe First Hospital of Lanzhou University, Lanzhou, Gansu, 730030, China.
Hai WangThe Second People's Hospital of Qingyang City, Qingyang City, Gansu, 745000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An electrochemical immunosensor was successfully developed for evaluating traditional Chinese medicine (TCM)-induced cardiac toxicity by immobilizing heart-type fatty acid-binding protein (HFABP)-specific antibodies on an electrode surface modified with chitosan (CS)-functionalized metal-organic framework ZIF-8 and gold nanoparticles (AuNPs). Leveraging the excellent biocompatibility of AuNPs, the excellent stability and high surface area of ZIF-8, along with the strong specific recognition capability of HFABP antibodies, the sensor demonstrated superior performance. Under optimized experimental conditions, it achieved an ultra-low detection limit of 7.09 × 10

Indexed as

Biosensing TechniquesCardiotoxicityDrugs, Chinese HerbalElectrochemical TechniquesFatty Acid-Binding ProteinsAnimalsAntibodies, ImmobilizedChitosanElectrodesGoldImmunoassayLimit of DetectionMedicine, Chinese TraditionalMetal NanoparticlesMetal-Organic FrameworksReproducibility of ResultsAntibodies, ImmobilizedChitosanDrugs, Chinese HerbalFatty Acid-Binding ProteinsGoldMetal-Organic FrameworksDrug-induced cardiac toxicityEarly warningElectrochemical immunosensorHeart-type fatty acid-binding protein (HFABP)Metal-organic framework material ZIF-8

Identifiers

PMID40900413

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.