Evidence map›Paper›PMID 40900476›Full record

SynthesisEinstein (Sao Paulo, Brazil)2025

Short-term effects of remote ischemic conditioning on vascular function in patients with cardiovascular diseases: a systematic review with meta-analysis.

Samuel Amorim, Gilberto Laurentino, Victor Sabino de Queiros, Yujia Liu, Per Aagaard, Charlotte Suetta, Naufal Zagidullin, Kenneth J Gollob

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Einstein (Sao Paulo, Brazil), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samuel AmorimHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-5510-8559
Gilberto LaurentinoUniversidade São Judas Tadeu, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-4225-7376
Victor Sabino de QueirosUniversidade Federal do Rio Grande do Norte, Natal, RN, Brazil.ORCID http://orcid.org/0000-0003-4117-0295
Yujia LiuDepartment of Physical Education, Jiangsu Normal University, Xuzhou, Jiangsu, China.ORCID http://orcid.org/0000-0001-6261-9827
Per AagaardDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Region Syddanmark, Denmark.ORCID http://orcid.org/0000-0002-9773-7361
Charlotte SuettaDepartment of Geriatrics, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0001-8063-6508
Naufal ZagidullinDepartment of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan, Russian Federation.ORCID http://orcid.org/0000-0003-2386-6707
Kenneth J GollobHospital Israelita Albert Einstein, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-4184-3867

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this systematic review with meta-analysis was to compare the short-term (≤1 month) effects of remote ischemic conditioning versus sham remote ischemic conditioning on vascular function in patients with cardiovascular diseases.

methodsA systematic review was conducted to identify relevant studies through six healthcare science databases up to March 2025. Arterial stiffness and endothelial function were defined as the primary outcome. Meta-analyses were performed using a random-effect model. Also, GRADE Pro software was used to evaluate the quality of evidence.

resultsA total of 7 randomized clinical trials with 603 patients with cardiovascular diseases were included in the systematic review. Also, we included 5 studies in the meta-analysis. Compared with sham remote ischemic conditioning or control, short-term remote ischemic conditioning resulted in enhanced endothelial function (MD=4.22% [95%CI=1.75; 6.69]; p=0.0008; I2=0%) without any changes in arterial stiffness, (MD=-0.05 m/s [95%CI =-0.77, 0.67]; p=0.89; I2=89%).

conclusionThis systematic review and meta-analysis found that short-term remote ischemic conditioning was associated with improvements in endothelial function compared with sham remote ischemic conditioning or control in cardiovascular patients, without any impact on arterial stiffness. PROSPERO DATABASE REGISTRATION: ID CRD42021234702.

Indexed as

Cardiovascular DiseasesEndothelium, VascularIschemic PreconditioningVascular StiffnessHumansRandomized Controlled Trials as TopicTime Factors

Identifiers

PMID40900476
PMCPMC12539847

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.