ReviewAnnals of medicine and surgery (2012)2025
Inflammatory cytokines and cardiac arrhythmias: from pathogenesis to potential therapies.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Inflammation-Mediated Mechanisms of Arrhythmias After Acute Myocardial Infarction.Reviews in cardiovascular medicine · 2026Review
- Impact of CaInternational journal of molecular sciences · 2026Review
- Review
- Pro- and Anti-Inflammatory Cytokines' Implication in Right Heart Disease, Arrhythmogenesis, and Atrial Fibrillation.Biomolecules · 2026Review
- Head-to-head comparison of the ability of the cardiometabolic index and triglyceride-glucose index to predict 3-year major adverse cardiovascular events in patients with atrial fibrillation: insights from a community cohort.Lipids in health and disease · 2026Article
- Association between systemic immune-inflammation index and ventricular premature contractions in patients without structural heart disease.Frontiers in cardiovascular medicine · 2026Article
- Dynamic evaluation of serum atherogenic factors as a predictor of QT interval prolongation in patients with type 2 diabetes mellitus.American journal of translational research · 2026Article
- Atrial fibrillation during palliative chemotherapy with utidelone: a case report.Frontiers in oncology · 2026Article
- Myocardial work abnormalities in rheumatoid arthritis with preserved left ventricular ejection fraction are more closely related to disease activity than to disease duration: a prospective cross-sectional study.Frontiers in medicine · 2026Article
- Analysis of selected cytokines, NLRP3 inflammasome and α-Klotho protein in patients with heart failure after ICD/CRT-D high-voltage intervention.Frontiers in physiology · 2025Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac arrhythmias, including atrial fibrillation and ventricular arrhythmias, are significant contributors to cardiovascular morbidity and mortality. Recent research has highlighted the critical role of inflammation in the pathogenesis of these arrhythmias, with inflammatory cytokines acting as key mediators. Cytokines such as interleukin-1, interleukin-6, tumor necrosis factor-alpha, and interleukin-17 are involved in promoting myocardial fibrosis, ion channel dysfunction, and autonomic dysregulation, which contribute to arrhythmic events. This review explores the relationship between inflammatory cytokines and cardiac arrhythmias, focusing on their molecular mechanisms, impact on heart tissue remodeling, and the role they play in arrhythmogenesis. Cytokine-induced inflammation leads to electrical and structural changes in the myocardium, which predispose the heart to arrhythmias. Elevated levels of pro-inflammatory cytokines can cause fibrosis, alter ion channel activity, and impair the normal conduction of electrical impulses. Additionally, cytokines enhance autonomic dysfunction, further increasing the risk of arrhythmia development. These findings underscore the significance of inflammation in the onset and progression of cardiac arrhythmias, particularly in conditions such as heart failure and atrial fibrillation, where persistent inflammation is prevalent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.