Evidence map›Paper›PMID 40901355›Full record

ArticleCase reports in clinical medicine2025

Clinically Meaningful Improvements in Long COVID Symptoms Following Ketogenic Metabolic Therapy Combined with Lifestyle Interventions-A Clinical Case Report and Review of the Literature.

Dana Dharmakaya Colgan, Diane D Stadler, Aluko A Hope, Heather Zwickey, Todd E Davenport, Thomas Weimbs

Abstract read
In one paragraph

Article in Case reports in clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dana Dharmakaya ColganHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.ORCID 0000-0002-6806-1542
Diane D StadlerSchool of Medicine, Oregon Health & Science University, Portland, OR, USA.
Aluko A HopeDivision of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
Heather ZwickeyHelfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Todd E DavenportDepartment of Physical Therapy, School of Health Sciences, University of the Pacific, Stockton, CA, USA.
Thomas WeimbsDepartment of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA, USA.

Funding

Building Research across Interdisciplinary Gaps (BRIDG) R90 Training Program - Administrative SupplementR90AT008924 · NCCIH · NATIONAL UNIVERSITY OF NATURAL MEDICINE · PI BRADLEY, RYAN D, ZWICKEY, HEATHER LEA · 2015 to 2025
$5.2M
Building Research across Interdisciplinary Gaps (BRIDG) T90/R90 Training ProgramT90AT008544 · NCCIH · UNIVERSITY OF WASHINGTON · PI BOOTH-LAFORCE, CATHRYN, BRADLEY, RYAN D · 2015 to 2023
$3.9M
Ketosis as a therapy for polycystic kidney diseaseR01DK124895 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI WEIMBS, THOMAS · 2020 to 2024
$2.2M
NCCIH NIH HHS R90 AT008924NCCIH NIH HHS T90 AT008544NIDDK NIH HHS R01 DK124895
6 · The paper itself

Abstract

Approximately 400 million individuals globally are estimated to suffer from Long COVID, an infection-associated chronic condition that occurs after SARS-CoV-2 infection. Despite the high burden, there are no evidence-based or FDA-approved interventions to treat the condition. Given its complexity, a multicomponent approach grounded in a whole-person health model is likely required. This case report highlights clinically meaningful improvements in multiple Long COVID symptoms following a remotely-delivered, ketogenic metabolic therapy combined with group health coaching. Nutritional interventions were paired with exercises to stabilize circadian rhythms and introduce mindfulness-based practices. A review of the literature provides evidence in support of ketogenic metabolic therapy and lifestyle interventions as strategies to target proposed underlying mechanisms of Long COVID and foster stress resilience, thus reducing symptoms and improving quality of life. Findings support future research to optimize and evaluate multimodal nutritional and lifestyle interventions for Long COVID.

Indexed as

DysautonomiaInfection-Associated Chronic IllnessKetogenetic Metabolic HealthLong COVIDMyalgia Encephalomyelitis/Chronic Fatigue Syndrome

Identifiers

PMID40901355
PMCPMC12400797

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.