Evidence map›Paper›PMID 40901537›Full record

ArticleFrontiers in human neuroscience2025

Impaired glymphatic system function and its association with speech and language delay in children with ADHD: a prospective study.

Yangchen Li, Jianhong Wang, Xinyu Yuan, Lili Zhang, Yuchun Yan, Yang Yang, Lin Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yangchen Li *Department of Radiology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Jianhong Wang *Center of Children's Healthcare, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Xinyu YuanDepartment of Radiology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Lili ZhangCenter of Children's Healthcare, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Yuchun YanDepartment of Radiology, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Yang YangDepartment of Medical Engineering, Capital Center for Children's Health, Capital Medical University, Beijing, China.
Lin WangCenter of Children's Healthcare, Capital Center for Children's Health, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The glymphatic system, a glial cell-dependent waste clearance pathway in the brain, is essential for the maintenance of brain homeostasis. This study aimed to explore the relationship between attention-deficit/hyperactivity disorder (ADHD) and its co-occurring clinical phenomena, including gross motor and language development, and the glymphatic system. Methods: A total of 56 children with ADHD and 33 age-and gender-matched typically developing (TD) children were included in this prospective study. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) was used to calculate the ALPS index, which evaluates glymphatic system function. The ALPS index of ADHD patients was compared with that of TD, and the correlation between the gross motor retardation and speech and language delay in ADHD patients and ALPS index was further analyzed. Results: The ALPS index in ADHD patients was significantly lower than that in TD children (1.503 ± 0.153 vs. 1.591 ± 0.152, Conclusion: Glymphatic system function may be impaired in ADHD patients. This study is the first to demonstrate that speech and language delay in ADHD patients may be associated with impaired glymphatic system function. Early intervention may be linked to better language trajectories in ADHD, providing a rationale for longitudinal trials to test causality.

Indexed as

ADHDcomorbidityDTI-ALPSglymphatic system functionspeech and language delay

Identifiers

PMID40901537
PMCPMC12399604

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.