SynthesisInternational journal of chronic obstructive pulmonary disease2025
Multi-Ancestry Mendelian Randomization Reveals Lipid-Associated Genetic Risk Factors for COPD.
Synthesis in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mendelian Randomization Study in East Asian Populations Supports the Causal Relationship Between Blood Metabolites and COPD: Insights from Amino Acids, Phospholipids, Vitamin D, and Trace Elements.International journal of chronic obstructive pulmonary disease · 2026Article
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7 authors.
Funding
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Abstract
Background: Previous Mendelian randomization (MR) studies investigating the causal relationship between lipid traits and chronic obstructive pulmonary disease (COPD) have primarily focused on individuals of European (EUR) ancestry, limiting the generalizability of findings. This study aimed to address this limitation. Methods: Summary-level data for individuals of East Asian (EAS), African (AFR), and Hispanic (HIS) ancestry were obtained from large-scale genetic databases. Lipid traits, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC), were derived from the Global Lipids Genetics Consortium (GLGC). The discovery COPD dataset was sourced from the Global Biobank Meta-analysis Initiative (GBMI), while replication datasets came from the Million Veteran Program (MVP) and Biobank Japan (BBJ). Causal effects were assessed through meta-analysis across discovery and replication cohorts, supplemented by a series of sensitivity analyses, including the Steiger test, Causal Analysis Using Summary Effect Estimates (CAUSE), MRLap, RadialMR, Bonferroni correction, among others. Results: In the EAS population, strong evidence supported a causal relationship between genetically predicted TC levels and reduced COPD risk (OR = 0.891, 95% CI: 0.841-0.944, Conclusion: This study reveals ancestry-specific causal links between lipid traits and COPD risk. The protective effect observed for TG in EAS may reflect variant-level pleiotropy rather than a true metabolic influence, warranting cautious interpretation. These findings highlight the importance of multi-ancestry analyses in contextualizing genetic associations across diverse populations.
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