Evidence map›Paper›PMID 40901685›Full record

ArticleWorld journal of gastroenterology2025

Important role of tumor deposits and negative lymph nodes in prognosis of N1c colorectal cancer patients.

Zhi-Gang Sun, Shao-Xuan Chen, Bai-Long Sun, Da-Kui Zhang, Ding-Rong Zhong, Tong-Yin Zhang, Yu-Wan Hu, Zi-Han Han, Wen-Xiao Wu, Zhi-Yong Hou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prognostic impact of tumor deposits in colorectal cancer.World journal of gastroenterology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhi-Gang SunDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
Shao-Xuan ChenDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
Bai-Long SunDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
Da-Kui ZhangDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
Ding-Rong ZhongDepartment of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.
Tong-Yin ZhangDepartment of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
Yu-Wan HuChinese Academy of Medical Science and Peking Union Medical College, China-Japan Friendship Hospital, Beijing 100730, China.
Zi-Han HanDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
Wen-Xiao WuChinese Academy of Medical Science and Peking Union Medical College, China-Japan Friendship Hospital, Beijing 100730, China.
Zhi-Yong HouDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
Li YaoDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
Ya-Jun ZhangDepartment of Anesthesiology, China-Japan Friendship Hospital, Beijing 100029, China.
Hong-Liang SunDepartment of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.
Jian-Zheng JieDepartment of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China. jianzhengjie@sohu.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe number of tumor deposits (TDs) does not play a part in the current tumor node metastasis staging. Negative lymph node (NLN) status is associated with the prognosis of colorectal cancer (CRC), but its clear role in N1c stage remains to be defined.

aimTo evaluate the combination of TDs and NLNs as potential prognostic indicators in N1c CRC.

methodsWe retrospectively identified 107 consecutive patients who had N1c CRC radically resected at China-Japan Friendship Hospital. The combination of TDs and NLNs was calculated by the formula NLNTD = NLN/(TD + 1). Cutoff values of NLNs and NLNTD were determined using the R package "survminer". Disease-free survival (DFS), overall survival (OS) and cancer-specific survival (CSS) were determined using the Kaplan-Meier method to assess the impact of NLNTD on prognosis. Results were compared using the log-rank test.

resultsThe median follow-up time was 63.17 (45.33-81.37) months for DFS, with 33.64% (36/107) of patients experiencing recurrence during follow-up. Five-year DFS was 66.0% (57.3%-76.0%). There was no significant difference in prognosis between patients with > 12 and ≤ 12 NLNs (

conclusionNLNTD could serve as important prognostic factor for outcomes in N1c CRC patients. These patients could be stratified for prognosis through NLNTD and the high-risk should be given more attention during treatment.

Indexed as

Colorectal NeoplasmsLymph NodesNeoplasm Recurrence, LocalAdultAgedAged, 80 and overChinaDisease-Free SurvivalFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLymphatic MetastasisLymph Node ExcisionMaleMiddle AgedColorectal cancerN1c stageNegative lymph nodePrognosisTumor deposits

Identifiers

PMID40901685
PMCPMC12400201

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.