ArticleMolecular biology of the cell2025
Acyl-CoA-binding protein AcbdA is required for peroxisome hitchhiking on early endosomes in
Bellana E Driscoll, Madison B Fountain, Isabella N Gates, Reihane Abdollahi, Allison M Langley, Matthew B Owens, Jenna R Christensen, John Salogiannis
Abstract read
In one paragraphArticle in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Bellana E DriscollDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.
Madison B FountainDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.
Isabella N GatesDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.
Reihane AbdollahiDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.
Allison M LangleyDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.
Matthew B OwensCellular, Molecular, and Biomedical Sciences Program, University of Vermont, Burlington, VT 05405.
Jenna R ChristensenDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208.
John SalogiannisDepartment of Molecular Physiology and Biophysics, University of Vermont Larner College of Medicine, Burlington, VT 05405.ORCID 0000-0002-1988-7284 Funding
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2MVermont Immunology/Infectious Diseases Training GrantT32AI055402 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GARY E WARD · 2005 to 2026
$2.7MIncreasing the Complexity of Microtubule-based transport: Cargo adaptors and Hitchhiking on Vesicles.R35GM150857 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JOHN SALOGIANNIS · 2023 to 2026
$1.7MEvolution of Cargo TransportR00GM140269 · NIGMS · NORTHWESTERN UNIVERSITY · PI Jenna Christensen · 2024 to 2026
$747kNIAID NIH HHS T32 AI055402NIGMS NIH HHS R00 GM140269NIGMS NIH HHS R01 GM129325NIGMS NIH HHS R35 GM150857
6 · The paper itselfAbstract
Motor-driven transport on microtubules is critical for distributing organelles throughout the cell. Most commonly, organelle movement is mediated by cargo adaptors, proteins on the surface of an organelle that directly recruit microtubule-based motors. An alternative mechanism called hitchhiking was recently discovered: some organelles move, not by recruiting the motors directly, but instead by using membrane contact sites (MCS) to attach to motor-driven vesicles and hitchhike along microtubules. Organelle hitchhiking is observed across fungi and animals. In filamentous fungi, nearly all peroxisomes move by hitchhiking on early endosomes (EE). In the fungus
Indexed as
Aspergillus nidulansDiazepam Binding InhibitorEndosomesFungal ProteinsPeroxisomesAcyl Coenzyme ABiological TransportCarrier ProteinsEndoplasmic ReticulumMembrane ProteinsMicrotubulesProtein TransportAcyl Coenzyme ACarrier ProteinsDiazepam Binding InhibitorFungal ProteinsMembrane Proteins
Identifiers
PMID40901736
PMCPMC12636676
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