Evidence map›Paper›PMID 40901759›Full record

ArticleHepatology (Baltimore, Md.)2025

Integrative Hepatology: Enhancing overall health to manage liver disease.

Jennifer C Lai, Elliot B Tapper, Puneeta Tandon

Abstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0003-2092-6380
Elliot B TapperDivision of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0839-1515
Puneeta TandonCirrhosis Care Clinic, Division of Gastroenterology and Hepatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-0486-0174

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
The Impact of Frailty on Liver Transplant Outcomes in Older Adults with Hepatocellular CarcinomaK24AG080021 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2023 to 2026
$755k
NIA NIH HHS K24 AG080021NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Despite remarkable advances in diagnostics, pharmacotherapy, and transplantation, conventional hepatology often falls short in addressing the persistent symptoms, impaired quality of life, and broader health needs of people living with chronic liver disease. Integrative Hepatology-rooted in the principles of integrative medicine-offers a holistic, evidence-informed approach that combines conventional hepatology with complementary modalities to address the biological, nutritional, physical, psychosocial, behavioral, and environmental determinants of liver health. This framework emphasizes multimodal, patient-centered care aimed at improving both liver-specific and overall health outcomes. We outline 3 models for implementation: (1) foundational knowledge for all hepatologists, incorporating core skills in nutrition, physical activity, and mind-body practices; (2) collaborative referral networks to integrative health providers; and (3) specialized hepatologists with advanced training in integrative medicine. Examples of application to fatigue, cramps, falls, and mental health in chronic liver disease illustrate the potential for non-pharmacologic and complementary strategies to enhance patient well-being. Implementation faces challenges, including evidence gaps, limited training, time constraints, reimbursement barriers, and inequitable access, but opportunities exist through education, interdisciplinary collaboration, group medical visits, and digital health delivery. By expanding the scope of liver care to include whole-person health, Integrative Hepatology seeks not to replace established therapies but to augment their impact-supporting patients in achieving optimal health across the disease spectrum.

Indexed as

complementary therapiesliver healthpatient-centered caresymptom managementwhole-person health

Identifiers

PMID40901759
PMCPMC12888997

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.