ArticleProceedings of the National Academy of Sciences of the United States of America2025
Procollagen IIA mediates positive feedback control of the mouse cardiogenic transcriptional network.
Alan W Leung, Sandra Y Wong, Janet C Zhang, Keith K H Leung, Nelson W F Dung, Catherine A Shang, Owen W Prall, Hieu T Nim, Michael See, Mirana Ramialison and 5 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Alan W Leung *School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.ORCID 0000-0003-3382-7947 Sandra Y Wong *School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Janet C Zhang *Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Keith K H LeungSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.ORCID 0000-0002-8960-3937 Nelson W F DungSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Owen W PrallDevelopmental and Regenerative Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.ORCID 0000-0003-1600-5933 Hieu T NimMurdoch Children's Research Institute, Novo Nordisk Foundation Centre for Regenerative Medicine (reNEW) and Department of Paediatrics, The University of Melbourne, Parkville, VIC 3000, Australia.
Michael SeeMurdoch Children's Research Institute, Novo Nordisk Foundation Centre for Regenerative Medicine (reNEW) and Department of Paediatrics, The University of Melbourne, Parkville, VIC 3000, Australia.
Mirana RamialisonMurdoch Children's Research Institute, Novo Nordisk Foundation Centre for Regenerative Medicine (reNEW) and Department of Paediatrics, The University of Melbourne, Parkville, VIC 3000, Australia.ORCID 0000-0001-6315-4777 Danny ChanSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.ORCID 0000-0003-3824-5778 Timothy J MohunThe Francis Crick Institute, London NW1 1AT, United Kingdom.
Richard P HarveyDevelopmental and Regenerative Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.ORCID 0000-0002-9950-9792 Patrick P L TamEmbryology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0001-6950-8388 Kathryn S E CheahSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.ORCID 0000-0003-0802-8799 Funding
Arthritis &Rheumatism Council ARC1994Australian Research Council (Discovery Project Grant) DP160100933Federal Government | DHAC | National Health and Medical Research Council (NHMRC) 1110751Federal Government | DHAC | National Health and Medical Research Council (NHMRC) 1180905Federal Government | DHAC | National Health and Medical Research Council (NHMRC) 354400 573705 573732 1074386 1118576 2008743National Heart Foundation of Australia (Heart Foundation) 107328Novo Nordisk Foundation (Australia) NNF21CC0073729Research Grants Council, University Grants Committee (ç"究資助局) HKU7275/00 M HKU7696/05 M AoE/M 04/04
6 · The paper itselfAbstract
Cardiogenesis relies on the integrated interplay between cardiac transcription factors and signaling pathways. Here, we uncover a role for type IIA procollagen (IIA), an extracellular matrix (ECM) protein encoded by an alternatively spliced
Indexed as
Collagen Type IIGene Regulatory NetworksHeartAnimalsBone Morphogenetic ProteinsFeedback, PhysiologicalGATA4 Transcription FactorGene Expression Regulation, DevelopmentalHomeobox Protein Nkx-2.5MiceOrganogenesisSignal TransductionTranscription FactorsTransforming Growth Factor betaBone Morphogenetic ProteinsCol2a1 protein, mouseCollagen Type IIGATA4 Transcription FactorHomeobox Protein Nkx-2.5Nkx2-5 protein, mouseTranscription FactorsTransforming Growth Factor betacardiac enhancerextracellular matrixheart developmenttranscriptional regulationtype II procollagen
Identifiers
PMID40901887
PMCPMC12440608
What Socratic holds
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