Evidence mapPaperPMID 40901952Full record

ArticleScience advances2025

Supplementing HIV-ART with cannabinoids increases serotonin, BHB, and Ahr signaling while reducing secondary bile acids and acylcholines.

Lakmini S Premadasa, Luis Romero, Mahesh Mohan

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lakmini S PremadasaSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0001-7435-5208
Luis RomeroSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0009-0005-4754-0287
Mahesh MohanSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0003-4360-3277

Funding

Tulane National Primate Research CenterP51OD011104 · TULANE UNIVERSITY OF LOUISIANA · 2025 to 2025
$9.3M
Texas Developmental Center for AIDS ResearchP30AI161943 · BAYLOR COLLEGE OF MEDICINE · 2025 to 2025
$1.0M
NIAID NIH HHS P30 AI161943NIDA NIH HHS R01 DA042524NIDA NIH HHS R01 DA052845NIH HHS P51 OD011104
6 · The paper itself

Abstract

Despite effective antiretroviral therapy (ART), people with HIV (PWH) experience persistent inflammation and metabolic dysfunction, increasing their risk for non-AIDS comorbidities. Accordingly, we evaluated the effects of long-term/low-dose Δ

Indexed as

Anti-Retroviral AgentsBile Acids and SaltsCannabinoidsHIV InfectionsReceptors, Aryl HydrocarbonSerotoninSignal TransductionAnimalsDronabinolHumansMacaca mulattaMaleSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnti-Retroviral AgentsBile Acids and SaltsCannabinoidsDronabinolReceptors, Aryl HydrocarbonSerotonin

Identifiers

PMID40901952
PMCPMC12407075

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.