Evidence map›Paper›PMID 40901969›Full record

ArticleScience advances2025

Galectin-3 induces neurodevelopmental apical-basal polarity and regulates gyrification.

Luana Campos Soares, Ning Huang, Hana Bernhardova, Viviana Macarelli, Marva Chan, Lara Nikel, Sara Bandiera, Dongnan Yan, Dhanu Gupta, Elisa M Cruz and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Luana Campos SoaresDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0001-9127-7061
Ning HuangDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.
Hana BernhardovaDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0009-0003-1797-9374
Viviana MacarelliDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0002-5875-8290
Marva ChanDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0001-8604-4300
Lara NikelDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0002-1577-2105
Sara BandieraDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0002-1203-8554
Dongnan YanDepartment of Pediatrics, University of Oxford, Oxford OX1 3QX, UK.
Dhanu GuptaInstitute of Developmental and Regenerative Medicine, University of Oxford, Oxford, UK.
Elisa M CruzDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.
Talia Vasaturo-KolodnerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.
James M HillisDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-0435-0879
Matthew WoodDepartment of Pediatrics, University of Oxford, Oxford OX1 3QX, UK.
Mootaz SalmanDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0002-5683-1706
Zoltán MolnárDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0002-6852-6004
Eric O'NeillDepartment of Oncology, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0002-0060-6278
Francis G SzeleDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.ORCID 0000-0002-2931-0673

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apical-basal polarity (ABP) establishment and maintenance is necessary for proper brain development, yet how it is controlled is unclear. Galectin-3 (Gal-3) has been previously implicated in ABP of epithelial cells, and, here, we find that it is apically expressed in human embryonic stem cells (hESCs) during neural induction. Gal-3 blockade disrupts ABP and alters the distribution of junctional proteins in hESC-derived neural rosettes and is rescued by addition of recombinant Gal-3. Transcriptomics analysis shows that blocking Gal-3 regulates expression of genes responsible for nervous system development and cell junction assembly, among others. Last, Gal-3 blockade during embryonic development in vivo reduces horizontal cell divisions, disturbs cortical layering of neural progenitors, and induces gyrification. These data uncover a regulatory mechanism for ABP in the brain and warrant caution in modulating Gal-3 during pregnancy.

Indexed as

Cell PolarityGalectin 3NeurogenesisAnimalsCell DifferentiationFemaleGene Expression Regulation, DevelopmentalHuman Embryonic Stem CellsHumansMiceNeural Stem CellsGalectin 3

Identifiers

PMID40901969
PMCPMC12407091

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.