Evidence map›Paper›PMID 40902897›Full record

ArticleJournal of advanced research2026

Alginate oligosaccharides prevent and treat obesity by promoting brown fat thermogenesis rather than regulating gut microbiota.

Yuncong Xu, Jun Jiang, Tao Li, Qiaojuan Yan, Zhengqiang Jiang, Shaoqing Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuncong XuKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Jun JiangKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Tao LiShandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.
Qiaojuan YanCollege of Engineering, China Agricultural University, Beijing 100083, China.
Zhengqiang JiangKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address: zhqjiang@cau.edu.cn.
Shaoqing YangKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China. Electronic address: ysq@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFunctional oligosaccharides may provide physiological benefits through several different mechanisms. However, the specific mechanisms of alginate oligosaccharides (AOSs) for the improvement of obesity remain unclear.

objectivesThe study aimed to evaluate the effects of AOSs with degrees of polymerization (DP) 2-4 on obesity and reveal the underlying mechanism.

methodsMice models of obesity prevention and treatment were used to determine the effects of AOSs on obesity. An antibiotic intervention was used to determine the role of gut microbiota. The therapeutic effect of intraperitoneal injection of AOSs on obesity was further explored.

resultsAOSs treatment (1, 000 mg/kg) could prevent and treat obesity, and the effects were comparable to that of an anti-obesity drug orlistat. AOSs treatment effectively reversed serum metabolic profiling, reduced lipid absorption in the small intestine and improved hepatic lipid metabolism disorders. The treatment also ameliorated systemic low-grade inflammation and oxidative stress, increased energy expenditure and improved mitochondrial function in brown adipose tissue. Moreover, broad-spectrum antibiotic intervention did not abrogate AOS-induced improvement in ameliorating obesity and intraperitoneal injection of AOSs ameliorated metabolic disorders, which highlighted that the ameliorative effect of AOSs on obesity might not be primarily dependent on gut microbiota.

conclusionOur findings provided first evidence that AOSs could prevent and treat obesity by reducing systemic low-grade inflammation and oxidative stress, and increasing brown adipose tissue energy expenditure, rather than regulating gut microbiota.

Indexed as

Adipose Tissue, BrownAlginatesGastrointestinal MicrobiomeObesityOligosaccharidesThermogenesisAnimalsAnti-Obesity AgentsDisease Models, AnimalEnergy MetabolismLipid MetabolismMaleMiceMice, Inbred C57BLOxidative StressAlginatesAnti-Obesity AgentsOligosaccharidesAlginate oligosaccharideEnergy expenditureGut microbiotaLipid metabolismObesity

Identifiers

PMID40902897
PMCPMC13316361

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.