Evidence map›Paper›PMID 40903286›Full record

ArticleMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2026

Perfusion Signal Analysis Using Multi-pulsed Arterial Spin Labeling (mPASL) with Multiple Post-labeling Delays: Phantom Validation and Application to the Human Foot.

Vadim Malis, Yoshiki Kuwatsuru, Mitsue Miyazaki

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vadim MalisDepartment of Radiology, University of California-San Diego, La Jolla CA, USA.
Yoshiki KuwatsuruDepartment of Radiology, University of California-San Diego, La Jolla CA, USA.
Mitsue MiyazakiDepartment of Radiology, University of California-San Diego, La Jolla CA, USA.

Funding

MR evaluation of macro- and micro-vascularity in diabetic peripheral artery diseaseR01HL154092 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MIYAZAKI, MITSUE · 2020 to 2023
$2.0M
Aging and Exercise Effects of Dural Lymphatic Clearance in Healthy Human and Diabetic BrainsR01AG076692 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mitsue Miyazaki · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL154092NIA NIH HHS R01 AG076692
6 · The paper itself

Abstract

purposeThis study aims to extend the general kinetic model (GKM) for perfusion signal analysis using multi-pulsed arterial spin labeling (mPASL) acquisitions with multiple post-labeling delays (mPLD). The approach aims to improve accuracy and gain potential for broader experimental and clinical applications.

methodsThe magnetization vector evolution of the mPASL technique was analyzed using sequence diagrams and numerical simulation, supplemented by static phantom experiments. The GKM was adapted to support different configurations of mPASL tagging pulses in "dark" and "bright" methods. The proposed approach was validated on a constant-flow phantom and applied to in-vivo foot perfusion measurements in a cohort of 5 healthy subjects.

resultsSimulations showed that the ratio between "dark" and "bright" mPASL methods is determined by fluid T

conclusionExtending the GKM to mPASL acquisitions demonstrates reliable performance under controlled constant flow conditions. Phantom experiments confirmed the accuracy of the approach, while in-vivo measurements in feet revealed deviations from simulation and constant flow results, suggesting the need to account for physiological factors and potential model extension due to pulsatile flow.

Indexed as

FootImage Processing, Computer-AssistedMagnetic Resonance ImagingAdultAlgorithmsComputer SimulationFemaleHealthy VolunteersHumansKineticsMalePerfusionPhantoms, ImagingReproducibility of ResultsSignal Processing, Computer-AssistedSpin LabelsSpin Labelsarterial spin labelingfoot perfusiongeneral kinetic modelmulti-pulsed arterial spin labelingperfusion

Identifiers

PMID40903286
PMCPMC13041248

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.