Trial reportBritish journal of anaesthesia2025
IMpact of PerioperAtive KeTamine on Enhanced Recovery After abdominal Surgery (IMPAKT ERAS): a pragmatic randomised single-cluster trial.
Trial report in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway
Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Moderate-to-severe Pain After Spinal Surgery: a Randomized Controlled Trial
Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Chronic Postsurgical Pain After Spinal Surgery: a Randomized Controlled Trial
Who cites it
2 citing papers in PubMed.
- Article
- IMpact of PerioperAtive KeTamine on Enhanced Recovery After abdominal Surgery (IMPAKT ERAS). Comment on Br J Anaesth 2025; 135: 1770-8.British journal of anaesthesia · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite widespread adoption of ketamine into enhanced recovery after surgery (ERAS) protocols, research regarding its specific impact on perioperative outcomes is limited. This pragmatic, randomised, double-blind, placebo-controlled, single-cluster trial evaluated the impact of ketamine on postoperative outcomes in patients undergoing major abdominal surgery within an established ERAS protocol.
methodsMale and female patients, aged ≥18 yr, were randomised to ketamine or saline placebo bolus at induction of general anaesthesia, followed by an intraoperative and postoperative infusion for 48 h. The primary outcome was hospital length of stay. Secondary outcomes included total opioid consumption and the incidences of side-effects and adverse events.
resultsA total of 1522 patients were included. In covariate adjusted analyses, ketamine administration did not decrease length of stay (odds ratio [OR] 1.21; 95% confidence interval [CI] 1.00-1.47) or opioid consumption (OR 0.85; 95% CI 0.71-1.01) compared with placebo. Patients receiving ketamine experienced higher odds of ICU transfer (OR 2.03; 95% CI 1.14-3.63) and lower odds of meeting early discharge milestones (OR 0.68; 95% CI 0.50-0.93). Rapid response activation (OR 1.51; 95% CI 0.85-2.68) and ileus requiring nasogastric decompression (OR 1.26; 95% CI 0.87-1.84) were similar between groups. Patients receiving ketamine experienced higher rates of debilitating dizziness (OR 6.05; 95% CI 3.02-12.11), debilitating hallucinations (OR 2.69; 95% CI 1.09-6.65), and other severe side-effects (OR 1.94; 95% CI 1.27-2.96).
conclusionsThe addition of ketamine to a multimodal abdominal ERAS protocol provided no significant benefits and was associated with worse perioperative outcomes. CLINICAL
trial registrationNCT04625283.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.