Evidence map›Paper›PMID 40903542›Full record

ArticlePharmaceutical research2025

Local Delivery of Non-opioid Analgesic Microparticles to Modulate Post-surgical Pain.

Prerna Mohan, Jeladhara Sobhanan, Caitlyn M Gaffney, Nitisha Mehrotra, Fernando J Cabrera, Richard Lee, Aparna Adumbumkulath, Eric Haas, Andrew J Shepherd, Crystal S Shin and 1 more

Abstract read
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Article in Pharmaceutical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Prerna MohanMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Jeladhara SobhananMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Caitlyn M GaffneyDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nitisha MehrotraMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Fernando J CabreraMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Richard LeeMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Aparna AdumbumkulathMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Eric HaasDivision of Colon and Rectal Surgery, Houston Colon, Houston, TX, USA.
Andrew J ShepherdDepartment of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Crystal S ShinMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. crystal.shin@bcm.edu.
Ghanashyam AcharyaMichael E. DeBakey Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA. gacharya@bcm.edu.

Funding

Southeast Clinical Research Associates 67591-I
6 · The paper itself

Abstract

purposePostsurgical pain (PSP) is a common complication in surgical patients that can progress to chronic pain and opioid dependence. Current analgesics, including opioids and non-opioid agents, are limited by short durations of action and adverse effects. This study reports the development and evaluation of extended-release bupivacaine microparticles (BuMPs) designed to provide sustained local analgesia and improve post-surgical pain management.

methodsBuMPs were fabricated using PLGA and tested in a mouse sciatic nerve injury (SNI) model, a clinically relevant model of neuropathic pain. Mice received a single local injection of BuMPs or blank microparticles. Mechanical hypersensitivity was assessed using the von Frey test over a 21-day period. BuMPs were also compared to an FDA-approved liposomal bupivacaine formulation.

resultsWe fabricated BuMPs by the hydrogel template method and confirmed their uniform size distribution. Thus prepared BuMPs exhibited extended bupivacaine release in vitro and in vivo in a healthy rat model. In a SNI model, BuMP-treated mice exhibited significantly reduced mechanical hypersensitivity compared to controls, with analgesic effects sustained for up to 21 days. BuMPs provided prolonged pain relief, demonstrating effective modulation of postsurgical and neuropathic pain.

conclusionsBuMPs offer a promising non-opioid strategy for long-acting PSP management. Their extended analgesic effect from a single perioperative injection may reduce opioid reliance, improve patient recovery, and serve as a complementary therapy.

Indexed as

Analgesics, Non-NarcoticAnesthetics, LocalBupivacaineNeuralgiaPostoperative PainAnimalsDelayed-Action PreparationsDisease Models, AnimalDrug LiberationMaleMiceParticle SizePolylactic Acid-Polyglycolic Acid CopolymerRatsRats, Sprague-DawleySciatic NerveAnalgesics, Non-NarcoticAnesthetics, LocalBupivacaineDelayed-Action PreparationsPolylactic Acid-Polyglycolic Acid CopolymerDrug deliveryMicroparticlesNon-opioidPain management

Identifiers

PMID40903542

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.