ReviewNature reviews. Gastroenterology & hepatology2025
Beyond preservation: future machine perfusion for liver assessment and repair.
Review in Nature reviews. Gastroenterology & hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Mathematical Modeling of Liver Metabolic Activity Under Ex Vivo Conditions upon Exposure to Magnetic Nanoparticles.Biomedicines · 2026Article
- Single-cell transcriptomic profiling reveals cellular stress responses to hypothermic preservation in liver-on-chip model.Scientific reports · 2026Article
- Nanomedicine in Organ Transplantation: From Graft Preservation and Repair to Immunomodulation and Monitoring.Theranostics · 2026Review
- Transplantation of older DCD livers in the machine perfusion era: a U.S. cohort study.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Ischemic preconditioning promotes hepatic differentiation in human liver organoids.Frontiers in cell and developmental biology · 2026Article
- Time as a Therapeutic Ally: The Promise of Long-Term Solid Organ and Tissue Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- [Research progresses in ex vivo liver perfusion technology].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Review
- Hepatic ischemia-reperfusion injury: Underlying mechanisms and concepts in liver surgery and liver transplantation.Hepatology (Baltimore, Md.) · 2025Article
- Xenoperfusion-The Transformative Role of Machine Perfusion in Xenotransplantation.XenotransplantationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Machine perfusion is an emerging and transformative technology for dynamic organ preservation, assessment and repair. Whereas allografts continuously degrade during static cold storage, short-term perfusion can preserve high-quality organs for hours, enabling assessment, regional transport and improved logistics. Long-term perfusion for multiple days might extend the potential of clinical machine perfusion in the future, allowing for the assessment, reconditioning and repair of marginal or injured grafts for which more time is needed. In addition, it might convert transplantation, which is now semi-elective thanks to short-term perfusion, to a fully elective procedure via customized machines and associated protocols that maintain organs ex situ for up to 2 weeks. The advent of long-term organ perfusion provides tremendous potential to improve organ evaluation and selection, to recondition or repair marginal grafts and, ultimately, to expand the pool of grafts available for transplantation. In this Perspective, we discuss design considerations, guidelines for use, and future perspectives of machine perfusion in the context of organ assessment and repair, with a focus on the liver.
Indexed as
Identifiers
40903588What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.