SynthesisEuropean journal of clinical pharmacology2025
Imeglimin systematic review: a novel therapeutic approach for type 2 diabetes-unveiling benefits on β-cell function, insulin sensitivity, and potential long-term glycaemic control (HbA1c).
Synthesis in European journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Insulin-reducing effect of adding imeglimin to ongoing dipeptidyl peptidase-4 inhibitor therapy with multiple daily insulin injections (INSPIRE study).Journal of diabetes investigation · 2026Article
- Potential of Triazines as Antidiabetic Agents-A Review of Structures and Pharmacological Activity.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Repurposing Imeglimin for Chemotherapy-Induced Cognitive Impairment: Targeting Mitochondrial Dysfunction and Neuroinflammation.Cellular and molecular neurobiology · 2026Review
- Smartphone-Based Colorimetric Determination of Imeglimin Hydrochloride Using Eosin Y: A Simple and Eco-Friendly Analytical Approach.Analytical science advances · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of diabetes mellitus has surged fourfold globally over the past 30 years, creating a major health concern. Imeglimin, a novel oral antidiabetic agent, has shown promising results in the management of type 2 diabetes mellitus (T2DM).
objectivesThis systematic review aimed to evaluate the efficacy and safety of imeglimin in patients with T2DM based on available clinical studies. METHODOLOGY: A total of 15 studies, including randomised clinical trials, observational studies, and retrospective analyses, were included in this review. These studies involved 2332 participants, predominantly with T2DM, aged 18 to 84 years. Imeglimin was administered at doses ranging from 500 to 3000 mg/day, either as monotherapy or in combination with other antidiabetic agents. The primary outcomes assessed were changes in glycated haemoglobin (HbA1c), fasting plasma glucose (FPG), and insulin sensitivity.
resultsImeglimin (500 to 3000 mg/day) demonstrated significant reductions in HbA1c levels, ranging from 0.44 to 1.1%, compared to placebo. FPG and glycated albumin also decreased significantly with imeglimin treatment. Improvements in insulin sensitivity and β-cell function were observed in both animal and human studies. Imeglimin was generally well tolerated, with no significant adverse effects on cardiac safety. However, gastrointestinal side effects, such as nausea, vomiting, and diarrhoea, were reported in some studies using imeglimin at doses above 2000 mg/day.
conclusionImeglimin appears to be an effective and safe treatment option for T2DM, offering a unique mechanism of action and the potential for use as monotherapy or in combination with other antidiabetic agents. Further long-term studies are needed to establish its sustained efficacy and safety profile.
Indexed as
Identifiers
40903650What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.