ArticleJournal of gastroenterology and hepatology2025
Helicobacter pylori Screening and Eradication in Junior High School Students in Yokosuka, Japan: Prevalence, Eradication Rates, and Challenges.
Article in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- AdolescentChildren (Basel, Switzerland) · 2026Review
- Helicobacter pylori Management in Older Adults: Current Perspectives From Japan.The Korean journal of helicobacter and upper gastrointestinal research · 2026Review
- Potassium-competitive acid blockers forFrontiers in cellular and infection microbiology · 2026Review
- Helicobacter pylori Screening and Eradication in Junior High School Students in Yokosuka, Japan: Prevalence, Eradication Rates, and Challenges.Journal of gastroenterology and hepatology · 2025Article
- Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori infection increases the risk of developing gastric cancer. Early eradication is effective in reducing the risk. An increasing number of Japanese municipalities are implementing school-based H. pylori screening programs. This study examined an administrative initiative targeting junior high school students to reveal the challenges in enhancing child-centered screening efforts. MATERIALS AND
methodsThis study examined a 2019-2021 population-based H. pylori screening program that targeted second-year junior high school students in Yokosuka City, Japan. The program used a two-tiered approach: initial urine antibody testing, followed by urea breath tests for confirmation. Students with confirmed infections received eradication therapy, and the outcomes were monitored through follow-up testing. Data on participation rates, treatment efficacy, side effects, and family infection surveys were analyzed.
resultsBetween 2019 and 2021, 6270 students in Yokosuka City participated in H. pylori screening, with a confirmed infection rate of 1.2%. First-line eradication therapy achieved a 52.9% success rate, which increased to 94.7% after the second-line treatment. Mild side effects, mainly diarrhea, were reported in 27.0% of the first-line and 22.0% of the second-line cases. Family surveys showed that 48.5% of the infected students had H. pylori-positive relatives, underscoring the importance of addressing familial transmission alongside treatment efforts.
conclusionsH. pylori has low prevalence among Japanese junior high school students in an urban area, with modest eradication success. The low participation and dropout rates highlight the need for improved strategies to boost engagement and ensure comprehensive screening and treatment for better program outcomes.
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Registered trials
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