ArticleAdvanced healthcare materials2026
Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin-Derived IKVAV Peptides.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hydrogels: current biomedical applications and future directions.Molecular biomedicine · 2026Review
- Synthetic PEG-4MAL Hydrogels Support Patient-Derived Human Intestinal Enteroid Culture.Cell biomaterials · 2026Article
- Lipoengineering of Biomolecular Condensates Controls Material Properties and Multiphase Hierarchy to Guide Organoid Morphogenesis.bioRxiv : the preprint server for biology · 2026Article
- Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.bioRxiv : the preprint server for biology · 2026Article
- Biomaterials in organoid research: current state and future directions.Frontiers in bioengineering and biotechnology · 2026Review
- Multiscale imaging of polarity in bovine oviductal organoids.Frontiers in cell and developmental biology · 2026Article
- Hydrogels with reversible stiffness modulation: new materials for studying dynamic mechanical cues that regulate cell behavior.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Intestinal organoids are three-dimensional cellular structures that are cultured in laminin-rich Matrigel, yielding organoids with correct, basal-out polarity. Removal of Matrigel results in organoids with reversed, apical-out polarity, demonstrating its vital role. However, Matrigel's composition is ill-defined, and its pathogenic origin poses challenges in reproducibility. Therefore, we here introduce a fully synthetic dynamic hydrogel that presents the IKVAV peptide as a laminin-mimic for guiding intestinal organoid polarity in a minimalistic, controlled manner. The ureido-pyrimidinone moiety is used to form supramolecular hydrogels that have orthogonal control over properties, like stiffness, ligand type and concentration. It is found that the IKVAV peptide combined with integrin activating antibody TS2/16 controls intestinal organoid polarity. Increasing hydrogel dynamics (stress-relaxing half-life time of ≈1000 to 30 s) further supports the growth of intestinal organoids with correct polarity, while a bulk level of stiffness (G' ≈0.7 kPa) is crucial to offer mechanical support. Through manipulation of integrins, it is revealed that the IKVAV-organoid interaction is integrin β1-mediated. Our findings demonstrate the essential role of the IKVAV motif in guiding intestinal organoid polarity in synthetic dynamic hydrogels - paving the way for the future design of synthetic systems to culture complex living tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.