Evidence map›Paper›PMID 40904190›Full record

ArticleCNS neuroscience & therapeutics2025

Parietal rTMS Induced Changes in Cortical Excitability in Patients With Minimally Conscious State Using TMS-EEG.

Ye Zhang, Xiaoping Wan, Yong Wang, Xiaoli Li, Jubao Du, Xiao Yan, Zilong Zhu, Yanhua Li, Weiqun Song

Abstract read
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ye ZhangDepartment of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Xiaoping WanDepartment of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Yong WangDepartment of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xiaoli LiState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.ORCID 0000-0003-1359-5130
Jubao DuDepartment of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Xiao YanDepartment of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Zilong ZhuDepartment of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Yanhua LiDepartment of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Weiqun SongDepartment of Rehabilitation Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China.

Funding

Beijing Hospital Authority Youth Programme QML20230813National Natural Science Foundation of China 82102658STI2030-Major Projects 2021ZD0204300
6 · The paper itself

Abstract

objectiveTo verify the effectiveness of the parietal repetitive transcranial magnetic stimulation (rTMS) and take advantage of TMS-EEG to assess cortical excitability in patients with minimally conscious states (MCS).

methodsWe enrolled 10 MCS patients who received 10 sessions of 10 Hz rTMS on the parietal cortex for 10 consecutive days and then 10 days of sham stimulation after a 14-day wash-out period. The Coma Recovery Scale-Revised (CRS-R) and TMS-EEG were used to assess the levels of consciousness and cortical excitability before and after active and sham stimulation, respectively.

resultsCompared to sham stimulation, the CRS-R revealed a significant improvement after receiving active rTMS. The amplitude of components of TMS-evoked potential after active stimulation significantly increased at 30, 60, and 180 ms, respectively; global brain power increased significantly. The PCIst values had a significant difference after active rTMS stimulation, and the CRS-R scores showed a significant correlation with PCIst values before and after active stimulation.

conclusionHigh-frequency rTMS on the parietal cortex has therapeutic efficacy and can improve cortical excitability in MCS patients. SIGNIFICANCE: Our results provide preliminary evidence to support the use of the parietal area as a potential therapeutic target for MCS patients in clinical practice.

Indexed as

Cortical ExcitabilityElectroencephalographyParietal LobePersistent Vegetative StateTranscranial Magnetic StimulationAdultAgedFemaleHumansMaleMiddle Agedcoma recovery scale‐revisedminimally conscious statesrepetitive transcranial magnetic stimulationTMS‐EEG

Identifiers

PMID40904190
PMCPMC12409070

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.