Evidence map›Paper›PMID 40904229›Full record

Observational studyBiomarkers in medicine2025

Electro-impedimetric detection of human anti-mycolate antibody biomarkers of TB before, during, and after treatment.

Carl Baumeister, Jan Verschoor, Veronica Ueckermann, Mosa Molatseli, Thoriso Sesing, Nomthandazo Khuboni, Bernard Fourie

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carl BaumeisterDepartment of Biochemistry, Genetics and Microbiology, Faculty of Natural & Agricultural Sciences, University of Pretoria, Pretoria, South Africa.
Jan VerschoorDepartment of Biochemistry, Genetics and Microbiology, Faculty of Natural & Agricultural Sciences, University of Pretoria, Pretoria, South Africa.
Veronica UeckermannDepartment of Internal Medicine (Division of Infectious Diseases), Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Mosa MolatseliMARTI TB Diagnostics, Pretoria, South Africa.
Thoriso SesingMARTI TB Diagnostics, Pretoria, South Africa.
Nomthandazo KhuboniMARTI TB Diagnostics, Pretoria, South Africa.
Bernard FourieDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study assessed electro-impedimetric detection (EIS-MARTI) of anti-mycolate antibodies (AMAb) in TB patients before, during, and after treatment, compared to sputum culture (MGIT) as the gold standard.

methodsA prospective pilot study enrolled 15 confirmed TB patients and 73 healthy controls at a Pretoria hospital (2016-2017). A prospective monitoring study followed 25 confirmed TB patients over 6 months of treatment at a Pretoria clinic (2019-2020) to evaluate biomarker behavior. Outcomes were analyzed using descriptive statistics, wherein diagnostic accuracy and predictive values were assessed by ROC curve analysis.

resultsEIS-MARTI detected 14/15 true TB-positive cases independent of HIV co-infection and 68/73 true TB-negatives in the pilot study. In the monitoring study, EIS-MARTI correlated with culture in 7/8 cases at treatment end, but not during the first 2 months.

conclusionAMAbs arise independently of HIV co-infection in active TB, recede during treatment, and are rapidly detected by a hand-held EIS-MARTI device. While suitability for treatment monitoring remains uncertain, EIS-MARTI shows promise for rapid, accurate TB diagnosis and confirming cure.

Indexed as

BiomarkersMycolic AcidsTuberculosisAdultAgedAntibodiesCoinfectionFemaleHIV InfectionsHumansMaleMiddle AgedPilot ProjectsRadioimmunoassayROC CurveSensitivity and SpecificityAntibodiesBiomarkersMycolic Acidsantibody biomarker for TBanti-mycolate antibodieshandheld TB diagnosticmycolic acidsTB immunosensorTB screeningTB serodiagnosisTuberculosis (TB)

Identifiers

PMID40904229
PMCPMC12416203

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.