ArticleCNS neuroscience & therapeutics2025
Intravenous Thrombolysis in Acute Ischemic Stroke: A Prognostic Prediction Model and the Role of Ischemic Core Growth Rate.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Intravenous Thrombolysis in Acute Ischemic Stroke: A Prognostic Prediction Model and the Role of Ischemic Core Growth Rate.CNS neuroscience & therapeutics · 2025Article
- Predicting intravenous thrombolysis outcomes in acute ischemic stroke using machine learning.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
aimsThe tissue window is increasingly recognized in guiding reperfusion therapy beyond the standard time window in acute ischemic stroke (AIS). This study aims to develop a nomogram incorporating an ischemic core growth rate index to provide individualized prediction of neurological outcomes in AIS patients who received intravenous thrombolysis (IVT).
methodsA retrospective study was conducted at the First Affiliated Hospital of Soochow University (2016-2023). A lasso-logistic method was employed for variable selection and model construction. The performance of the model was evaluated using the receiver operating characteristic curve, calibration curve, decision curve analysis, and compared with a conventional indexed one.
resultsThe study cohort comprised 553 patients with favorable outcomes (median ischemic core growth rate: 1.4 [0.5, 4.1] mL/h) and 198 patients with poor outcomes (median ischemic core growth rate: 5.7 [1.1, 14.2] mL/h). The nomogram included diabetes, TOAST classification, ischemic core growth rate, neutrophil count, direct bilirubin, and NIHSS score at admission. It achieved an AUC of 0.882 (95% CI: 0.855-0.908), outperforming the conventional indexed one. Calibration showed good agreement between predicted and observed outcomes (Hosmer-Lemeshow p = 0.851).
conclusionIschemic core growth rate strongly correlates with neurological prognosis in AIS. This nomogram offers reliable predictions for IVT outcomes.
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Registered trials
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