Evidence mapPaperPMID 40904382Full record

ArticleEJHaem2025

Late-Onset Invasive Aspergillosis With Pituitary Involvement and Dysfunction Following CD19 Chimeric Antigen Receptor T-Cell Therapy.

Daisuke Ikeda, Tomohiro Nawada, Takumi Kondo, Takayuki Shinohara, Tomohiro Nagano, Saya Kubota, Ryuichiro Hiyama, Masaya Ueno, Hiroki Kobayashi, Keisuke Seike and 7 more

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Daisuke IkedaDepartment of Hematology, Oncology and Respiratory Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.ORCID https://orcid.org/0000-0002-7398-4616
Tomohiro NawadaThe Center for Graduate Medical Education Okayama University Hospital Okayama Japan.ORCID https://orcid.org/0000-0001-8676-0825
Takumi KondoDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Takayuki ShinoharaDepartment of Fungal Infection National Institute of Infectious Diseases Tokyo Japan.
Tomohiro NaganoDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Saya KubotaDepartment of Hematology, Oncology and Respiratory Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
Ryuichiro HiyamaDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Masaya UenoDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Hiroki KobayashiDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Keisuke SeikeDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Hideaki FujiwaraDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Noboru AsadaDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.ORCID https://orcid.org/0000-0001-7322-5460
Daisuke EnnishiDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Keiko FujiiDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Nobuharu FujiiDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.
Masanori MakitaDepartment of Hematology Chugoku Central Hospital Hiroshima Japan.
Yoshinobu MaedaDepartment of Hematology and Oncology Okayama University Hospital Okayama Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Invasive fungal infection (IFI) after chimeric antigen receptor (CAR) T-cell therapy is less common than bacterial and viral infections, but can be fatal once it develops. As most cases occur within 30 days after CAR T-cell infusion, late-onset IFI-particularly mould infection-appears to be under-recognised. Discussion: We report an illustrative case of pituitary aspergillosis developing as late as one year after CD19 CAR T-cell therapy, highlighting a persistent risk in certain patients with delayed immune reconstitution. Conclusion: This case underscores the need for continued vigilance and individualised antifungal strategies to prevent IFI beyond the early post-infusion period. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.

Indexed as

aspergillosisCD19 CAR Tinvasive fungal infectionpituitary

Identifiers

PMID40904382
PMCPMC12404041

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.