ReviewClinical and experimental hepatology2025
Hepatitis E in the pediatric population: An overlooked disease but a genuine concern?
Review in Clinical and experimental hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Hepatitis E virus seroprevalence in South Africa: a multi-site study among HIV-negative and HIV-positive adults and age-stratified children (2-17 Years).BMC infectious diseases · 2026Article
- When serology misleads: cross-reactivity in acute hepatitis.Archives of virology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis E virus (HEV) is a significant yet underdiagnosed cause of acute and chronic hepatitis, particularly in pediatric populations. While HEV infection in children is often asymptomatic or mild, it can progress to severe outcomes in immunocompromised patients, such as organ transplant recipients or those undergoing chemotherapy. HEV genotypes 1 and 2 are predominantly responsible for waterborne outbreaks in endemic regions, whereas genotypes 3 and 4 are associated with zoonotic transmission in developed countries. Emerging evidence also links HEV to extrahepatic manifestations, including neurological, renal, hematological, and pancreatic complications. Diagnosis remains challenging due to frequent asymptomatic presentation and limitations in serological testing, highlighting the importance of polymerase chain reaction (PCR)-based detection. Although vaccination shows promise, especially in endemic areas, its availability remains limited for pediatric populations. Addressing research gaps and improving surveillance, prevention, and treatment strategies are critical for reducing HEV-related morbidity in children.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.