ArticleBiomedical reports2025
Conserved methylation signature accurately predicts heavily irradiated CNS tumour with perplexing histopathology: A case report.
Article in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Methylation profiling in neuropathological tumors diagnosis: a comprehensive review.Frontiers in oncology · 2025Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosing central nervous system (CNS) tumours post-radiation therapy is often complicated by treatment-induced histological changes. Molecular diagnostics, such as methylation profiling, offer robust tools to aid in accurate tumour classification. The present study reported a case of a 48-year-old woman with a recurrent parasellar mass previously treated with stereotactic radiosurgery. Despite imaging suggestive of meningioma, histopathology and immunohistochemistry yielded ambiguous findings. Low-coverage whole genome methylation profiling using Oxford Nanopore sequencing provided a conclusive diagnosis of meningioma, with a classifier confidence score of 0.791, supported by t-distributed stochastic neighbor embedding clustering and characteristic copy number variations. The present case illustrated the diagnostic utility of methylation profiling in post-treatment CNS tumours with perplexing histopathology. Integration of molecular diagnostics can enhance classification accuracy and inform clinical decision-making.
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