Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Lashodya V DissanayakeDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.ORCID 0000-0002-2329-0931
Adrian ZietaraDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.ORCID 0000-0002-7465-060X
Ruslan BohovykDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.ORCID 0000-0002-3999-4570
Christine A KlemensDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.
Olha KravtsovaDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.ORCID 0000-0002-4280-9399
Vladislav LevchenkoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.
Melissa LoweDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.ORCID 0009-0001-3854-3559
Abigail ShapiroDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.ORCID 0009-0009-1311-0034
Vera PasmanikDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.
Oleg PalyginDivision of Nephrology, Department of Medicine (O.P.), Medical University of South Carolina, Charleston, SC.ORCID 0000-0002-3680-5527
Ilse S DaehnBarbara T. Murphy Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY (I.S.D.).ORCID 0000-0001-9915-5376
Ashraf El-MeanawyDivision of Nephrology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI (A.E.-M.).ORCID 0000-0002-3114-5312
Timo RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.ORCID 0000-0001-6082-662X
Alexander StaruschenkoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine (L.V.D., A.Z., R.B., C.A.K., O.K., V.L., M.L., A. Shapiro, V.P., T.R., A. Staruschenko), University of South Florida, Tampa, FL.ORCID 0000-0002-5190-8356
Funding
Training in Research on Vascular Inflammation and InjuryT32HL160529 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · 2022 to 2025
$688k
Sexual dimorphisms and role of the cGAS-STING pathway in diabetic nephropathyR01DK135644 · UNIVERSITY OF SOUTH FLORIDA · 2025 to 2025
$513k
Genetic risk and molecular characterization of Diabetic Kidney DiseaseR01DK139395 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$338k
Renal diabetic complications mediated by the PAR1 signaling in podocytesR01DK129227 · UNIVERSITY OF SOUTH FLORIDA · 2025 to 2025
backgroundAsymptomatic hyperuricemia is associated with poor outcomes in kidney and cardiovascular diseases, but its causative role remains controversial. Clinical studies have shown a positive correlation between increased dietary sodium intake and urinary uric acid excretion, suggesting that hyperuricemia may influence salt-sensitive hypertension and associated kidney damage.
methodsTo study the effects of mild hyperuricemia on salt-sensitive hypertension, male and female Dahl SS rats were fed a diet containing a uricase inhibitor (2% oxonic acid) and 4% NaCl (high salt) or a high salt-only diet for 3 weeks. Analyses were conducted using radiotelemetry, immunohistochemistry, and RNA-Sequencing.
resultsUricase inhibition resulted in a ≈3.5-fold increase in plasma uric acid levels in both sexes compared with their respective high salt controls. However, only the male high salt/oxonic acid group exhibited a significant increase in uric acid excretion. The mild hyperuricemia significantly attenuated the progression of hypertension in male but not female rats. The male high salt/oxonic acid group showed reduced kidney hypertrophy and protein cast formation, indicating mitigated kidney damage. Supplementation with oxonic acid reduced oxidative damage in the tubules, as evidenced by the decreased fluorescence intensity of 8-oxodG. RNA-Sequencing analyses of male kidneys revealed that oxonic acid administration was associated with increased expression of genes linked to the activation of various vasodilatory pathways.
conclusionsOur study demonstrates that in male, but not female, Dahl salt-sensitive rats, mild hyperuricemia accompanied by hyperuricosuria slowed the progression of salt-sensitive hypertension, potentially due to reduced kidney damage.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Mild Hyperuricemia Attenuates Salt-Sensitive Hypertension and Kidney Damage. · full record | Socratic