ArticleCNS neuroscience & therapeutics2025
Activation of Locus Coeruleus-Hippocampus Tyrosine Hydroxylase Projection Contributes to the Surgical Incision Pain-Induced Memory Consolidation Enhancement in Mice.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Activation of Locus Coeruleus-Hippocampus Tyrosine Hydroxylase Projection Contributes to the Surgical Incision Pain-Induced Memory Consolidation Enhancement in Mice.CNS neuroscience & therapeutics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
aimsThe mechanism underlying postoperative post-traumatic stress disorder (PTSD) remains unclear. However, studies have shown that acute postoperative pain is an independent risk factor for PTSD, which is also closely related to memory consolidation enhancement. Preoperative patients often experience unpleasant traumatic events, and postoperative pain usually occurs in the memory consolidation stage of these events. Therefore, inquiring whether acute postoperative pain affects memory consolidation and its possible mechanism may help to explain the causes of postoperative PTSD. METHODS AND
resultsIn this study, we show that the surgical incision pain enhances the consolidation of emotional memory (in the passive avoidance test) and nonemotional memory (in the novel object recognition test) in mice. None of the behaviors evaluated were affected by anxiety or locomotor dysfunction (in the open-field test). Besides, we confirmed that surgical incision pain promotes memory enhancement by enhancing memory consolidation instead of memory retrieval. Furthermore, the consolidation of emotional memory and nonemotional memory was enhanced by the activation of the LC-HPC TH projection after surgical incision pain. Hippocampal CA1 dopamine receptors, rather than β adrenoceptors, mediate emotional and nonemotional memory consolidation enhancement after surgical incision pain.
conclusionThus, our results indicate that surgical incision pain enhances the memory consolidation of emotional memory and nonemotional memory in mice. Activation of the LC-HPC TH projection may contribute to memory consolidation enhancement induced by surgical incision pain, which involves the activity of dopamine receptors in CA1.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.