Evidence map›Paper›PMID 40905474›Full record

ReviewAdvanced healthcare materials2026

Transforming Cancer Diagnosis and Therapy Through Fluorescent Hydrogels: A Review.

Elahe Masaeli, Seshasai Srinivasan, Amin Reza Rajabzadeh

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elahe MasaeliSchool of Biomedical Engineering, McMaster University, 1280 Main Street West Hamilton, Hamilton, ON, L8S 4L8, Canada.
Seshasai SrinivasanSchool of Biomedical Engineering, McMaster University, 1280 Main Street West Hamilton, Hamilton, ON, L8S 4L8, Canada.
Amin Reza RajabzadehSchool of Biomedical Engineering, McMaster University, 1280 Main Street West Hamilton, Hamilton, ON, L8S 4L8, Canada.ORCID 0000-0002-5371-3245

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2019
6 · The paper itself

Abstract

Recent decades have witnessed a revolution in oncological care and control, with new drug transport systems, advanced functional imaging, and next-generation biosensors. At the forefront of this revolution is the development of engineered hydrogels that intricately mimic the tumor microenvironment. These hydrogels are drawing significant attention in preclinical, diagnostic, and therapeutic applications in cancer. By integrating fluorescent agents, these hydrogels enable real-time tracking and enhanced imaging, paving the way for advancements in cancer diagnostics and therapeutic monitoring. Fluorescent hydrogel-based biosensors can monitor tumor bulk, assess tumor targeting by therapeutics, and distinguish between the initial and later effects of cancer treatment early in its progression. By encapsulating antibodies, biomarkers, or small molecules within fluorescent-labeled hydrogel structures, these systems achieve unprecedented levels of detection and imaging precision. Fluorescent hydrogels are also utilized to deliver chemotherapeutic drugs, immunosuppressants, hyperthermia-inducing agents, photodynamic therapy compounds, and other therapeutics, enabling localized, on-demand controlled release for cancer treatment and drug release monitoring. This review examines the methods for fluorescent labeling of hydrogels and explores the latest applications of fluorescent hydrogels in cancer treatment, biorecognition, and visualization. Finally, it discusses the primary challenges and potential future progression of fluorescent hydrogels for cancer management.

Indexed as

Fluorescent DyesHydrogelsNeoplasmsAnimalsBiosensing TechniquesDrug Delivery SystemsHumansFluorescent DyesHydrogelscancerdiagnosticsfluorescenthydrogeltreatments

Identifiers

PMID40905474
PMCPMC12790332

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.