Evidence map›Paper›PMID 40905697›Full record

ArticleMicrobiology spectrum2025

Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis.

Ting Ji, Ting-Ting Zhao, Sheng-Ze Long, Cai-Zhou Wei, De-Yun Cheng, Juan Chen, Liang-Jian Kuang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ting Ji *Department of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Ting-Ting Zhao *Department of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Sheng-Ze Long *Department of Pulmonary and Critical Care Medicine, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, Guangxi, China.
Cai-Zhou WeiDepartment of Pulmonary and Critical Care Medicine, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, Guangxi, China.
De-Yun ChengDepartment of Pulmonary and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-4460-491X
Juan ChenDepartment of Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.ORCID 0000-0001-5801-9124
Liang-Jian KuangDepartment of Pulmonary and Critical Care Medicine, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, Guangxi, China.ORCID 0000-0002-1402-536X

Funding

Natural Science Foundation of Ningxia Hui Autonomous Region in 2024 2024AAC05083Natural Scientific Foundation of China 81860016Scientific Research Funding Project of Ningxia Medical University XT2024032
6 · The paper itself

Abstract

The inflammatory cytokine storm is a hallmark of sepsis and is highly correlated with organ injury. Therefore, inhibiting inflammatory cytokine production is a straightforward strategy for effectively treating this disease. In this study, we found that microvesicles from lipopolysaccharide (LPS)-primed macrophages could transfer mitochondria to other macrophages and alter their biological functions. Microvesicles were isolated from LPS-primed macrophages and characterized by transmission electron microscopy. The function of microvesicle-transferred mitochondria in macrophages was evaluated by assessing the expression levels of inflammatory cytokines using immunofluorescent and quantitative real-time polymerase chain reaction (RT-qPCR) assays, and metabonomics using

Indexed as

Cell-Derived MicroparticlesMacrophagesMembrane ProteinsMitochondriaNucleotidyltransferasesSepsisAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytokinesHumansInterferon-betaLipopolysaccharidesMaleMetforminMiceMice, Inbred C57BLcGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytokinesInterferon-betaLipopolysaccharidesMembrane ProteinsMetforminNucleotidyltransferasesReactive Oxygen SpeciesSting1 protein, mouseSTING Proteinmetabolismmetforminmicrovesiclesmitochondriasepsis

Identifiers

PMID40905697
PMCPMC12502667

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.