ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
MIG-6 Plays a Critical Role as a PGR Mediator in Maintaining Epithelial and Stromal Cells for Uterine Receptivity.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Ovarian steroid hormones-estrogen and progesterone-play a central role in regulating epithelial-stromal interactions in the uterus. These interactions are critical for uterine function, including endometrial receptivity, implantation, and decidualization. These interactions involve complex signaling crosstalk between the uterine epithelium and the underlying stroma, with dynamic cell population-specific roles. Mitogen-inducible gene 6 (MIG-6) is a key mediator of progesterone signaling in the endometrium, and loss of MIG-6 results in implantation failure due to a non-receptive endometrium. To investigate whether MIG-6 deficiency disrupts the complex and dynamic cell population-specific roles of uterine cells, we performed single-cell RNA sequencing to characterize the cellular composition and functional alterations in the non-receptive endometrium of uterine-specific Mig-6 knockout (Pgr
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