Evidence mapPaperPMID 40906150Full record

ReviewBiology2025

In Vivo Shadows and In Vitro Light: The Early Embryological Journey Amid Endometriosis.

Grzegorz Mrugacz, Aleksandra Mospinek, Maria Modrzyńska-Olejniczak, Bartłomiej Byczkowski, Ewelina Radaj, Piotr Olcha

Abstract readReview
In one paragraph

Review in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Grzegorz MrugaczCenter for Reproductive Medicine Bocian, Białystok Branch, 26 Akademicka St., 15-267 Białystok, Poland.
Aleksandra MospinekCenter for Reproductive Medicine Bocian, Łódź Branch, 157a Piotrkowska St., 90-440 Łódź, Poland.
Maria Modrzyńska-OlejniczakCenter for Reproductive Medicine Bocian, Łódź Branch, 157a Piotrkowska St., 90-440 Łódź, Poland.
Bartłomiej ByczkowskiCenter for Reproductive Medicine Bocian, Łódź Branch, 157a Piotrkowska St., 90-440 Łódź, Poland.
Ewelina RadajCenter for Reproductive Medicine Bocian, Lublin Branch, 26 Relaksowa St., 20-819 Lublin, Poland.
Piotr OlchaCenter for Reproductive Medicine Bocian, Lublin Branch, 26 Relaksowa St., 20-819 Lublin, Poland.ORCID 0000-0003-0552-2855

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis significantly impacts fertility through complex mechanisms. These include chronic inflammation, oxidative stress, and anatomical distortion. These mechanisms impair oocyte quality, embryo development, and implantation. While in vivo challenges persist, in vitro fertilization (IVF) offers a controlled environment to overcome some barriers. A systematic review of evidence is presented for (1) endometriosis-associated oocyte dysfunction, (2) conflicting IVF outcomes, and (3) innovative strategies. Significant medical advancements have been made. However, gaps remain in personalized prognosis and targeted therapies. Emerging tools, specifically AI-driven embryo selection, single-cell omics, and immunomodulation, are promising for improving outcomes. Hence, a patient-centered approach, balancing science with personalized care, is essential to navigate endometriosis-related infertility.

Indexed as

embryo morphokineticsendometriosisinfertilityin vitro fertilization (IVF)oocyte qualityoxidative stresstranscriptomics

Identifiers

PMID40906150
PMCPMC12383735

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.