Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Ryan MehlemDepartment of Bioengineering, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0002-0243-262X
Andrew BoysiaDepartment of Bioengineering, Clemson University, Clemson, SC 29634, USA.
Mugdha V PadalkarDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA.ORCID 0000-0003-2043-0801
Achala PokhrelDepartment of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, SC 29634, USA.
Jing Echesabal-ChenDepartment of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, SC 29634, USA.
Anne VonadaPapé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0003-0398-1898
Alexis StamatikosDepartment of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0003-0162-8521
Olga V SavinovaDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA.
Markus GrompePapé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-6616-4345
Renee N CottleDepartment of Bioengineering, Clemson University, Clemson, SC 29634, USA.ORCID 0000-0002-7971-2865
Funding
Statistical Methods for Gene Regulatory Analysis From Single Cell Genomics DataP20GM139769 · NIGMS · CLEMSON UNIVERSITY · PI ANHOLT, ROBERT R. H, ARNO, GAVIN · 2021 to 2025
$10.8M
Nonviral Delivery of CRISPR-Cas9 into Hepatocytes Combined with APAP Selection for Treatment of Familial HypercholesterolemiaR01HL168093 · NHLBI · CLEMSON UNIVERSITY · PI Renee Nicole Cottle · 2024 to 2026
$1.9M
American Association for the Study of Liver Diseases Foundation 2021000920American Society of Gene & Cell Therapy 2022000099NHLBI NIH HHS 1R01HL168093-01A1NHLBI NIH HHS 1R56HL168093-01NHLBI NIH HHS R01 HL168093NIGMS NIH HHS P20 GM139769
6 · The paper itself
Abstract
We previously demonstrated lipid nanoparticle-mediated CRISPR-Cas9 gene editing to disrupt the gene encoding cytochrome P450 oxidoreductase (Cypor), combined with transient administration of acetaminophen (APAP), to repopulate the liver with healthy hepatocytes and rescue a phenylketonuria mouse model. This study aimed to investigate electroporation-mediated delivery of
Indexed as
atherosclerosisCRISPR-Cas9electroporationfamilial hypercholesterolemiagene editinghepatocyte transplantationliver research
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
One Shock, Not One Cure: Electroporation Reveals Disease-Specific Constraints in Hepatocyte Gene Editing Therapy. · full record | Socratic