Evidence map›Paper›PMID 40908288›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.

M Catalina Camacho, Elina Deshpande, Michael T Perino

Abstract readReview
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Neural mechanisms underlying decisions to express or suppress emotions.Social cognitive and affective neuroscience · 2026
    Article
  2. Trajectories of mental health and mental illness: where we are now and where we go next.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M Catalina CamachoDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA. camachoc@wustl.edu.ORCID 0000-0003-0457-5410
Elina DeshpandeDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Michael T PerinoDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.

Funding

A computational model for how risk for anxiety and depression influences affective neurodevelopmentDP5OD037370 · OD · WASHINGTON UNIVERSITY · PI Maria Catalina Camacho · 2024 to 2026
$1.9M
Reward motivations associated with bullying trajectoriesR00HD105002 · NICHD · WASHINGTON UNIVERSITY · PI PERINO, MICHAEL T · 2023 to 2025
$732k
Reward motivations associated with bullying trajectoriesK99HD105002 · NICHD · WASHINGTON UNIVERSITY · PI PERINO, MICHAEL T · 2021 to 2022
$239k
NICHD NIH HHS K99 HD105002NICHD NIH HHS R00 HD105002NIH HHS DP5 OD037370U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HD105002U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) OD037370
6 · The paper itself

Abstract

Humans are intensely social creatures. It is therefore not surprising that many psychiatric disorder criteria include social dysfunctions; however, overlapping presentations and diverse, complex etiologies make treating social dysfunctions difficult. Here, we introduce the Cognitive Affective Social Processing and Emotion Regulation (CASPER) model. CASPER integrates research from social psychology, cognitive neuroscience, and developmental science to describe how real-world social processing unfolds and is associated with differing psychiatric social cognitive neurophenotypes. Briefly, social processing can be broken down into the following cognitive steps: identifying relevant social cues, attending to related cues, interpreting cues, and adjusting behavior appropriately. Each of these steps is influenced by the individual's affect and goals in the moment, which in turn influence which social concept or schema is activated for that interaction. Concepts are formed across development as we learn social skills and gain life experience. This model therefore links early experiences to social dysfunction "in the moment". The goal of this model is to provide a testable scientific framework for psychiatric research into social dysfunctions, as well as provide a model that generates new treatment targets for improving interventions and reinterpreting differences based on the extant research.

Indexed as

CognitionEmotional RegulationEmotionsModels, PsychologicalSocial BehaviorSocial CognitionHumans

Identifiers

PMID40908288
PMCPMC12618608

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.