Evidence map›Paper›PMID 40908298›Full record

ArticleBritish journal of cancer2025

CDCP1/mitochondrial Src axis increases electron transport chain function to promote metastasis in triple-negative breast cancer.

Jordan A Woytash, Austin E Y T Lefebvre, Ziang Zhang, Binzhi Xu, Stephanie A Harchenko, Hoa T Le, Andrew R McColloch, Xiaoyu Shi, Michelle A Digman, Olga V Razorenova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jordan A WoytashDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-1276-947X
Austin E Y T LefebvreDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Ziang ZhangDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA.
Binzhi XuDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA.
Stephanie A HarchenkoDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA.
Hoa T LeDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA.
Andrew R McCollochDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Xiaoyu ShiDepartment of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Michelle A DigmanDepartment of Biomedical Engineering, University of California, Irvine, CA, USA.
Olga V RazorenovaDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA. olgar@uci.edu.ORCID http://orcid.org/0000-0002-9442-6170

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING · 2007 to 2016
$25.1M
Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Gel-based Optical-isolation Single-Cell 3D Spatial MultiomicsDP2GM150017 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SHI, XIAOYU · 2022 to 2025
$2.6M
Elucidating How Primary Cilia Regulate Hedgehog Signaling by Super-Resolution MicroscopyR00GM126136 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SHI, XIAOYU · 2020 to 2022
$746k
Elucidating How Primary Cilia Regulate Hedgehog Signaling by Super-Resolution MicroscopyK99GM126136 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHI, XIAOYU · 2018 to 2019
$128k
California Breast Cancer Research Program (CBCRP) 25IB-0059Elsa U. Pardee Foundation (Pardee Foundation) EUPF-5714644National Science Foundation (NSF) 1847005National Science Foundation (NSF) DGE-1839285NCATS NIH HHS UL1 TR001414NCATS NIH HHS UM1 TR004927NCI NIH HHS P30 CA062203NCI NIH HHS T32 CA009054NIGMS NIH HHS DP2 GM150017NIGMS NIH HHS K99 GM126136NIGMS NIH HHS P50 GM076516NIGMS NIH HHS R00 GM126136U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) T32CA009054
6 · The paper itself

Abstract

backgroundTriple-negative type of breast cancer (TNBC) has limited therapeutic options and frequently metastasizes, leading to low survival rates. Oxidative phosphorylation (OXPHOS) is a driver of TNBC metastasis, but the signaling underlying this metabolic change is poorly understood.

methodsWe performed metabolic assays and assessed migratory and metastatic potential in cells with manipulated CDCP1/mitochondrial Src signaling.

resultsWe show that the pro-metastatic cell surface protein CUB-domain containing protein 1 (CDCP1) activates Src kinase localized in mitochondria, which potently induces OXPHOS and TNBC migration. Genetic targeting of either CDCP1 or mitochondrial Src, as well as pharmacological inhibition of Src reduce OXPHOS in vitro. We further show that mitochondrial Src increases OXPHOS by stimulating Complex I activity in the electron transport chain. Importantly, rescuing Complex I activity in cells devoid of CDCP1/mitochondrial Src signaling restores both OXPHOS and migration. We also provide evidence that NAD

conclusionsBoth CDCP1 and mitochondrial Src represent potential therapeutic targets to inhibit OXPHOS-mediated TNBC metastasis.

Indexed as

Antigens, CDAntigens, NeoplasmCell Adhesion MoleculesMitochondriaNeoplasm Proteinssrc-Family KinasesTriple Negative Breast NeoplasmsAnimalsCell Line, TumorCell MovementElectron TransportElectron Transport Complex IFemaleHumansNeoplasm MetastasisOxidative PhosphorylationAntigens, CDAntigens, NeoplasmCDCP1 protein, humanCell Adhesion MoleculesElectron Transport Complex INeoplasm Proteinssrc-Family Kinases

Identifiers

PMID40908298
PMCPMC12530134

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.