ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Nutritional indicators as predictive and prognosis biomarkers for neoadjuvant chemoradiotherapy outcomes in patients with locally advanced rectal cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Pretreatment comprehensive nutritional index predicts survival in locally advanced rectal cancer after neoadjuvant chemoradiotherapy and surgery.Biomolecules & biomedicine · 2026Article
- Predictive value of NRI, NLR, PLR and LMR for therapeutic efficacy and prognosis in advanced rectal cancer patients treated with PD-1/PD-L1 immunotherapy.Frontiers in surgery · 2026Article
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Authors and funding
4 authors.
Funding
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Abstract
purposeThis study aimed to investigate the association between the change ratios of nutritional indicators and the efficacy of neoadjuvant chemoradiotherapy (nCRT) and survival in patients with locally advanced rectal cancer (LARC).
methodsThis study comprised 208 LARC patients with serial measurements of nutritional indicators including red blood cell count (RBC), hemoglobin (HB), platelet count (PLT), prognostic nutritional index (PNI), and body mass index (BMI). Stratification by pathological response was followed by Cox regression modeling for survival analysis (DFS/OS) and logistic regression for nCRT response prediction. The receiver operating characteristic (ROC) curves were used to measure the prediction power of the independent nutritional markers.
resultsMultivariate logistic regression analysis confirmed RBC and HB were independent predictors for the efficacy of nCRT. RBC and HB were used to predict the area under the ROC curve of the efficacy of nCRT, which was greater than the single indicator prediction of the change ratio of RBC or HB. Multivariate Cox regression analyses revealed that HB was significantly associated with DFS and OS in LARC patients.
conclusionRBC and HB independently predicted the efficacy of nCRT and HB was significantly associated with DFS and OS in patients with LARC. Patients maintaining optimal nutritional parameters throughout the treatment exhibited significantly improved nCRT response rates and survival outcomes.
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