ArticleJournal of the American Heart Association2025
Associations Between Hematologic Parameters and All-Cause Death in Individuals With Cardio-Renal-Metabolic Multimorbidity: A National Cohort Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association Between Naples Prognostic Score and All-Cause Mortality in Individuals with Cardio-Renal-Metabolic Multimorbidity: A Cohort Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Association between clinical characteristics within 6 h of ICU admission and 30-day mortality risk in immunocompromised sepsis patients: development and validation of a machine learning model based on the MIMIC-IV database.Frontiers in digital health · 2026Article
- Serum total bile acids within the normal range are inversely associated with inflammatory indices and Gensini score in patients with premature coronary artery disease.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardio-renal-metabolic multimorbidity is common and a major cause of death. This study investigates the associations between hematologic parameters and all-cause death, aiming to redefine complete blood count reference intervals for individuals with cardio-renal-metabolic multimorbidity.
methodsThe study cohort consisted of 4482 adults drawn from the National Health and Nutrition Examination Survey conducted between 1999 and 2018. To assess the associations of hemoglobin concentration, platelet count, white blood cell count, and systemic inflammatory response index with the risk of all-cause death, multivariable Cox regression and restricted cubic spline regression analyses were used. Subgroup and sensitivity analyses were performed to ensure the robustness of the findings.
resultsOver a median follow-up of 71 (36-121) months, 2025 deaths (42%) occurred. After adjusting for potential confounding variables, participants with hemoglobin of ≥13.7 g/dL, platelet count of 228-356×10
conclusionsAlterations in hematologic parameters are significantly correlated with all-cause death in patients with cardio-renal-metabolic multimorbidity. Keeping these parameters within optimal ranges greatly reduces the mortality rate, highlighting the importance for clinicians managing patients with cardio-renal-metabolic multimorbidity to closely monitor hematologic changes and implement appropriate interventions.
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