Evidence map›Paper›PMID 40908813›Full record

ReviewPharmacogenomics

Pharmacogenomics of buprenorphine - a narrative review.

Lakshmi Aravindan, Sanjana Velu, Inesh Sivam, Sahana Sivam, Pooja S Tallapaneni, Ruthie Ressler, Michael Marks, Raman Venkataramanan, Rupa Radhakrishnan, Senthilkumar Sadhasivam

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacogenomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lakshmi AravindanDepartment of Biosciences, Rice University, Houston, TX, USA.
Sanjana VeluPre-medical Medical Program, Pennsylvania State University, University Park, PA, USA.
Inesh SivamNorth Allegheny High School, Pittsburgh, PA, USA.
Sahana SivamNorth Allegheny High School, Pittsburgh, PA, USA.
Pooja S TallapaneniUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ruthie ResslerDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael MarksDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Raman VenkataramananDepartment of Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA.
Rupa RadhakrishnanDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Senthilkumar SadhasivamDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

Implementing and Personalizing Best-In-Class Opioid-sparing Pain Management for Major Inpatient Surgeries in ChildrenU01HD116257 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Vidya Chidambaran, Senthilkumar Sadhasivam · 2024 to 2026
$10.0M
Perioperative Precision Medicine: Translating Science to Clinical Practice to Improve Safety and Efficacy of Opioids in Neonates, Children and Nursing MothersU01TR003719 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Senthilkumar Sadhasivam · 2022 to 2026
$4.4M
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use DisorderR01DA059321 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Rupa Radhakrishnan, Senthilkumar Sadhasivam · 2023 to 2026
$4.2M
Effects of Opioid Use Disorder in Pregnancy on Long-Term Maternal and Child OutcomesR01HD096800 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2022
$3.1M
Development and Commercialization of a pupillometer to predict postoperative opioid-induced respiratory depression in childrenR44DA055407 · NIDA · NEUROPTICS, INC. · PI OLIVER, JEFFREY WADE, PRIVITERA, CLAUDIO · 2022 to 2024
$2.7M
Reduction of opioid requirement associated with Auriculo-nerve stimulation following open surgeryR01DA054513 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHELLY, JACQUES E., SADHASIVAM, SENTHILKUMAR · 2022 to 2025
$2.1M
Improving Analgesic Effectiveness and Safety with Proactive Precision Pain Management in Thoracic Surgical Patients with Lung LesionsR43HL167661 · NHLBI · OPALGENIX, INC. · PI PLUMP, STEVEN R., SADHASIVAM, SENTHILKUMAR · 2023 to 2023
$644k
Enhancing pain management for knee replacement patients through an innovative non-invasive and opioid-sparing deviceR41DA059303 · NIDA · NCAP MEDICAL, LLC · PI CHELLY, JACQUES E., SADHASIVAM, SENTHILKUMAR · 2024 to 2024
$416k
Avoiding Adverse Opioid Outcomes with Proactive Precision CareR41DA053877 · NIDA · OPALGENIX, INC. · PI PLUMP, STEVEN R., SADHASIVAM, SENTHILKUMAR · 2021 to 2022
$374k
Reducing Opioid Use and Adverse Effects through Proactive Precision Pain Management Following Spine SurgeryR44DA056280 · NIDA · OPALGENIX, INC. · PI PLUMP, STEVEN R., SADHASIVAM, SENTHILKUMAR · 2022 to 2022
$327k
Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in PregnancyR43DA058430 · NIDA · OPALGENIX, INC. · PI PLUMP, STEVEN R., SADHASIVAM, SENTHILKUMAR · 2023 to 2023
$325k
Neuroimaging in Pregnancy to Assess Effects of Opioid Use DisorderR03DA056797 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI RADHAKRISHNAN, RUPA · 2023 to 2023
$238k
NCATS NIH HHS U01 TR003719NHLBI NIH HHS R43 HL167661NICHD NIH HHS R01 HD096800NICHD NIH HHS U01 HD116257NIDA NIH HHS R01 DA054513NIDA NIH HHS R01 DA059321NIDA NIH HHS R03 DA056797NIDA NIH HHS R41 DA053877NIDA NIH HHS R41 DA059303NIDA NIH HHS R43 DA058430NIDA NIH HHS R44 DA055407NIDA NIH HHS R44 DA056280
6 · The paper itself

Abstract

Buprenorphine, a semi-synthetic opioid, is used to treat Opioid Use Disorder (OUD) and as an analgesic. Buprenorphine's benefits over other opioids include longer duration of action, lower abuse potential, and a ceiling effect to serious adverse effects such as respiratory depression. This is a literature review of gene variants affecting the pharmacokinetics and pharmacodynamics of buprenorphine from databases, such as PubMed. Genetic polymorphisms related to metabolism and receptor binding of buprenorphine can alter the pharmacokinetics and response to buprenorphine. Specifically, genetic variants in

Indexed as

Analgesics, OpioidBuprenorphineOpioid-Related DisordersPharmacogeneticsGlucuronosyltransferaseHumansPolymorphism, GeneticAnalgesics, OpioidBuprenorphineGlucuronosyltransferaseBuprenorphinegene variantsopioidopioid maintenance therapypersonalized analgesiapharmacodynamicspharmacogenomicspharmacokinetics

Identifiers

PMID40908813
PMCPMC12427432

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.