Evidence map›Paper›PMID 40908905›Full record

ArticleThe plant genome2025

Analysis of candidate genes identified via genome-wide association analysis of sugar-related traits in maize kernels.

Dan Lv, Jingyun Luo, Songqin Liu, Ran Zheng, Aoni Zhang, Bo Tong, Qingping Zeng, Xinyi Liu, Hongbing Luo, Min Deng

Abstract read
In one paragraph

Article in The plant genome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dan LvCollege of Agronomy, Hunan Agricultural University, Changsha, China.
Jingyun LuoNational Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan Agri-Matrix Technology Co., Ltd., Wuhan, China.
Songqin LiuCollege of Agronomy, Hunan Agricultural University, Changsha, China.
Ran ZhengCollege of Agronomy, Hunan Agricultural University, Changsha, China.
Aoni ZhangCollege of Agronomy, Hunan Agricultural University, Changsha, China.
Bo TongCollege of Agronomy, Hunan Agricultural University, Changsha, China.
Qingping ZengCollege of Agronomy, Hunan Agricultural University, Changsha, China.
Xinyi LiuCollege of Agronomy, Hunan Agricultural University, Changsha, China.
Hongbing LuoCollege of Agronomy, Hunan Agricultural University, Changsha, China.
Min DengCollege of Agronomy, Hunan Agricultural University, Changsha, China.ORCID https://orcid.org/0009-0002-8489-6045

Funding

China Postdoctoral Science Foundation 2022M711122National Natural Science Foundation of China 32101700Postgraduate Scientific Research Innovation Project of Hunan Province CX20230697The Science and Technology Innovation Program of Hunan Province YLS-2025-ZY04040
6 · The paper itself

Abstract

Maize (Zea mays L.) is a globally significant crop, with its kernel sugar content playing a crucial role in determining nutritional quality and industrial applications. This study aimed to elucidate the genetic mechanisms underlying sugar-related traits in maize kernels through genome-wide association studies. We evaluated 495 maize inbred lines for reducing sugar content, soluble sugar content, and the reducing/soluble sugar ratio. Phenotypic analysis revealed substantial variation, with coefficients of variation ranging from 28.84% to 53.86%, and high broad-sense heritability (87.90%-93.98%). Using 12,617,573 high-quality single-nucleotide polymorphisms, we identified 93 significant quantitative trait nucleotides associated with these traits. Transcriptomic data from the maize inbred line B73 highlighted six candidate genes (Zm00001d040189, Zm00001d032517, Zm00001d052399, Zm00001d028974, Zm00001d036971, and Zm00001d022316) with high expression during kernel development. Protein-protein interaction and coexpression network analyses suggested that these genes are involved in metabolic processes, cell communication, and carbohydrate metabolism. Haplotype analysis further revealed that the optimal haplotypes of the six candidate genes could increase the kernel sugar content without affecting the yield traits of maize. These findings advance our understanding of the genetic basis of sugar-related traits in maize and offer valuable molecular markers for future breeding programs.

Indexed as

Genes, PlantSeedsSugarsZea maysCarbohydrate MetabolismGenome-Wide Association StudyPhenotypePolymorphism, Single NucleotideQuantitative Trait LociSugars

Identifiers

PMID40908905
PMCPMC12411998

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.