ReviewFrontiers in aging neuroscience2025
Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review.
Review in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Determinants of Speech Perception Outcomes After Hearing Aid Fitting in Conductive and Sensorineural Hearing Loss: A Prospective Longitudinal Observational Study.Audiology research · 2026Article
- Systemic immune-inflammation index and neutrophil-to-lymphocyte ratio predict treatment responses in elderly patients with profound sudden deafness.Experimental and therapeutic medicine · 2026Article
- Presbycusis Across the Lifespan: Genetic, Molecular, and Multi-Omics Contributions.Audiology research · 2026Review
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- [Analysis of characteristics and influencing factors of hearing loss in the older adults].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Autophagy in Sensorineural Hearing Loss: Jekyll or Hyde?International journal of molecular sciences · 2026Review
- Genetic and Environmental Factors Shaping Hearing Loss: Xenobiotics, Mechanisms and Translational Perspectives.Journal of xenobiotics · 2026Review
- Cochlear Inflammatory Microenvironment in Age-Related Hearing Loss: Mechanisms and Recent Advances.Clinical interventions in aging · 2026Review
- cAMP-MFN2 signaling suppresses cochlear cell senescence and age-related hearing loss.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related hearing loss (ARHL), or presbycusis, is characterized by a progressive decline in binaural auditory sensitivity, particularly affecting high-frequency hearing and sound localization. The pathogenesis of ARHL is still unclear, correspondingly reflected in a lack of clinically effective intervention strategies. Recent advancements in audiology and neurobiology have illuminated the black box of the pathogenesis of ARHL. The intricate mechanisms underlying ARHL involve inflammation, oxidative stress, excessive autophagy, cellular signaling dysregulation, and metabolic alterations, which cause substantial damage to cellular function within cochlea. The weakened sound conduction and reduced auditory information processing potentially lead to emotional distress and heightened susceptibility to neurodegenerative conditions like cognitive decline and dementia. Promising interventions targeting these mechanisms are actively being investigated, ranging from pharmacological approaches to genetic therapies and lifestyle interventions. This narrative review summarizes recent research progress in understanding ARHL pathogenesis and discusses emerging strategies for prevention and treatment, highlighting the imperative for targeted interventions to enhance auditory health and overall well-being in aging populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.