ArticleFrontiers in neurology2025
Serum uric acid to high-density lipoprotein cholesterol ratio is associated with stroke in the elderly: a population-based study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Uric acid-to-HDL cholesterol ratio and incident stroke: Competing-risk models in the China Health and Retirement Longitudinal Study.Medicine · 2026Article
- Association of serum uric acid to high density lipoprotein cholesterol ratio with stroke.Scientific reports · 2026Article
- Dibutyl phthalate induces sarcopenia via TNFα/TNFR1-mediated proteolytic and pyroptotic axes: evidence from NHANES and experimental models.Frontiers in immunology · 2026Article
- Association between monocyte-to-high-density lipoprotein cholesterol ratio and stroke: a propensity score matched cross-sectional study.Frontiers in neurologyArticle
- Serum uric acid-to-HDL cholesterol ratio and stroke prevalence: NHANES 1999-2018 with external support from an imaging-confirmed hemorrhagic stroke dataset.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The ratio of serum uric acid (UA) to high-density lipoprotein cholesterol (HDL-c), known as UHR, has been identified as a novel marker for oxidative stress and metabolic disorders. This study focused on exploring the association between UHR and stroke risk among older adults in the United States. Methods: This cross-sectional study utilized data from individuals aged 60 years and older, collected through the 1999-2018 National Health and Nutrition Examination Survey (NHANES). Stroke assessment was based on participants' self-reported history. The association between UHR and stroke risk was analyzed using logistic regression, restricted cubic splines (RCS), subgroup analysis, and receiver operating characteristic (ROC) curves. Results: This study included a total of 16,562 older adults, and the proportion of stroke cases increased with higher UHR levels. After adjusting for confounders, multivariable logistic regression analysis revealed that individuals in the highest UHR quartile had an odds ratio of 1.48 (1.23-1.80) for stroke risk compared to those in the lowest quartile. Subgroup analyses further demonstrated a stronger association in non-diabetic populations. RCS analysis suggested a linear relationship. Based on ROC results, UHR outperformed UA and HDL-c. Conclusion: Higher UHR levels are strongly associated with an increased risk of stroke in older adults. Additional large-scale prospective studies are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.