ArticleCureus2025
Genetic Association and Causal Effects Between Obesity and Multiple Sclerosis: A Robust Two-Sample Mendelian Randomization Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
1 author.
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Abstract
backgroundA relationship between obesity, as measured by body mass index (BMI), and multiple sclerosis (MS) has been reported in several observational studies. This study aimed to investigate the potential causal relationship between BMI and the risk of developing MS using a Mendelian randomization (MR) approach. MATERIALS AND
methodsA two-sample MR analysis was performed using single nucleotide polymorphisms (SNPs) associated with the exposures - BMI and MS - sourced from publicly available genome-wide association studies (GWAS) at a genome-wide significance threshold of
resultsThe MR analysis revealed a causal effect of BMI on MS as indicated by IVW (odds ratio (OR) = 1.39; 95% confidence interval (CI) = 1.23, 1.58; P = 1.42e-07), IVW method with modified second-order weights (IVW (Mod.2nd)) (OR = 1.39; 95% CI = 1.28, 1.51; P = 2.31e-15), MR-Egger (OR = 1.39; 95% CI = 1.01, 1.92; P = 4.51e-02), MR-Genotype Recoding Invariance Property (MR-GRIP) (OR = 1.41; 95% CI = 1.21, 1.65; P = 1.80e-05), MR-PRESSO (OR = 1.39; 95% CI = 1.28, 1.51; P = 3.79e-14), MR-RAPS (OR = 1.39; 95% CI = 1.24, 1.56; P = 2.66e-08), and GSMR (OR = 1.38; 95% CI = 1.23, 1.55; P = 3.35e-08). No evidence of horizontal pleiotropy or heterogeneity was detected, and the findings were confirmed to be robust.
conclusionThis study provides evidence that an increase in body size (BMI) can lead to MS. Therefore, maintaining a healthy weight during early life could be a potential strategy to reduce MS risk.
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