ArticleJournal of biomedical optics2025
Mapping functional hemodynamic and metabolic responses to dementia: a broadband spectroscopy pilot study.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Introduction to Special Issue on Metabolic Imaging and Spectroscopy, 2025.Journal of biomedical optics · 2025Article
- Brain network analysis in Alzheimer's disease and mild cognitive impairment using high-density diffuse optical tomography.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: Broadband near-infrared spectroscopy (bNIRS) can simultaneously monitor several chromophores, including the oxidative state of cytochrome c-oxidase (oxCCO), an oxygen metabolism biomarker, the activity of which is altered in Alzheimer's disease. Being a portable and noninvasive neuromonitoring technique, bNIRS could provide accessibility to brain-specific biomarkers and aid in the dementia diagnostic pathway. Aim: We use bNIRS-recorded functional hemodynamic and oxCCO changes to assess their relevance in Alzheimer's disease diagnosis. Approach: Using a visual stimulus paradigm, we recorded functional changes in oxy-, deoxy-hemoglobin and oxCCO in three similarly aged cohorts: healthy controls ( Results: We found individual variations in peak amplitude and time-to-peak for all the stimulus-evoked bNIRS signals across the three cohorts. CCA showed a strong correlation between bNIRS features and the clinical cognitive markers ( Conclusions: oxCCO could be a crucial biomarker, partly explaining cognitive differences with dementia. bNIRS uniquely provides a portable and noninvasive technique to monitor several chromophores simultaneously, including oxCCO, with potential future applications in diagnosing and tracking dementia progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.