Evidence map›Paper›PMID 40909275›Full record

ArticleFrontiers in immunology2025

Assessing the impact of TET2 and TET3 deletion in TCRalpha and TCRbeta repertoire in murine CD4 T cells in physiological and pathophysiological conditions.

Tarmo Äijö, Marianthi Gioulbasani, Jair Ernesto Valenzuela, Ageliki Tsagaratou

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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tarmo Äijö *Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Marianthi Gioulbasani *Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jair Ernesto Valenzuela *Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Ageliki TsagaratouLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Funding

Epigenetic Regulation of Lineage SpecificationR35GM138289 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TSANGARATOU, AGELIKI · 2020 to 2024
$2.0M
NIGMS NIH HHS R35 GM138289
6 · The paper itself

Abstract

Ten Eleven Translocation (TET) proteins can oxidize 5-methylcytosine to generate in sequential steps oxidized forms of cytosine: 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine. Through their catalytic activity TET proteins promote active DNA demethylation. There are three TET proteins: TET1, TET2 and TET3. In T cells, TET2 and TET3 are more highly expressed. In the past years we have extensively analyzed the impact of TET proteins and 5-hydroxymethylcytosine in T cell development. In this report, we focus on the impact of TET proteins in the TCR alpha (α) and beta (β) repertoires in thymic CD4 single positive cells and upon migration in the periphery. Our data reveal that both wild type and

Indexed as

CD4-Positive T-LymphocytesDioxygenasesDNA-Binding ProteinsProto-Oncogene ProteinsReceptors, Antigen, T-Cell, alpha-betaAnimalsMiceMice, Inbred C57BLMice, KnockoutThymus GlandDioxygenasesDNA-Binding ProteinsProto-Oncogene ProteinsReceptors, Antigen, T-Cell, alpha-betaTet2 protein, mouseTet3 protein, mouseTCR clonalityTCR diversityTCR oligoclonal expansionTCR sequencingTET proteins

Identifiers

PMID40909275
PMCPMC12405334

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.