ReviewFrontiers in immunology2025
Comprehensive review of macrophage models: primary cells and immortalized lines across species.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed.
- Virulence attenuation in ST11-K64Virulence · 2026Article
- Autophagy and ubiquitination in important swine viral infections: Host defense and viral antagonism.Virulence · 2026Review
- Virulence determinants of Fusarium oxysporum for clinical infections.PLoS pathogens · 2026Article
- Inhibitory Efficacy of Medicinal Plant Extracts from the Family Acanthaceae Against Skin Pathogenic Bacteria, Antioxidant and Anti-Inflammatory Activities.Plants (Basel, Switzerland) · 2026Article
- Induced pluripotent stem cell-derived macrophages (iMacs) in translational medicine: Disease models, drug testing, and therapeutic applications.Molecular biology reports · 2026Review
- Macrophage-Based Transcriptional Assays for the Comparative Assessment of the Anti-Inflammatory Paracrine Activity of Canine Adipose-Derived Mesenchymal Stromal Cells.Biomolecules · 2026Article
- Bacteria-mimicking cancer cells reprogram macrophages via multiple pattern recognition receptor pathways for cancer immunotherapy.Signal transduction and targeted therapy · 2026Article
- Article
- Epigenetic Reprogramming byAntibiotics (Basel, Switzerland) · 2026Review
- AUBFM01 Phage as a Therapeutic Candidate Against MDRMicroorganisms · 2026Article
- Dual immune armies in glaucoma: microglia and monocyte-derived macrophages.Frontiers in immunology · 2026Review
- Exploring macrophage polarization: biological insights, key laboratory techniques and research perspectives.Frontiers in immunology · 2026Review
- Proteomic and morphologic characterization of ovine macrophage differentiation and polarization.Scientific reports · 2025Article
- Phosphorylation of the βScientific reports · 2025Article
- Robust, scalable and xeno-free protocol for differentiating human induced pluripotent stem cells into functional macrophages.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to preserve homeostasis, macrophages-phagocytic innate immune cells-interact with different tissue types, modulating immunological responses and secreting a variety of cytokines. They are extensively dispersed throughout the body's tissues and organs. Based on their developmental origins, tissue-resident macrophages (TRMs) in humans can be classified into those of embryonic origin and those derived from bone marrow-derived monocytes (BMDMs); embryonically derived macrophages emerge during early development, possess self-renewal capacity, and persist into adulthood in specific tissues such as microglia in the brain and Kupffer cells in the liver, whereas BMDMs originate from hematopoietic stem cells in the bone marrow via monocytic differentiation, infiltrate tissues during inflammation or injury, and differentiate into macrophages that transiently reside in tissues but lack self-renewal capability, thus requiring continuous replenishment. Because of their flexibility and diversity, macrophages participate in a variety of physiological and pathological processes by changing phenotypically and functionally in response to microenvironmental stimuli. This process is known as macrophage polarization. As a consequence, macrophage cultivation
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.